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The GBM thickening decreases tissue strain per unit of transcapillary pressure drop according to the law of Laplace, but increases the transcapillary pressure drop required to maintain glomerular filtration. The model results are in agreement with the observed GBM alterations in Alport syndrome and thin basement membrane disease, and the model-predicted linear relation between the inverse capillary radius and inverse capillary thickness at equilibrium is consistent with published data on different mammals. In addition, the model predicts a minimum achievable strain in the GBM based on the geometry, properties, and mechanical environment; that is, an infinitely thick GBM would still experience a finite strain. Although the model assumptions would be invalid for an extremely thick GBM, the minimum achievable strain could be significant in diseases, such as Alport syndrome, characterized by focal GBM thickening. Finally, an examination of reasonable values for the model parameters suggests that the oncotic pressure drop\u2014the osmotic pressure difference between the plasma and the filtrate due to large molecules\u2014plays an important role in setting the GBM strain and, thus, leakage of protein into the urine may be protective against some GBM damage.<\/jats:p>","DOI":"10.1115\/1.4007098","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T22:08:03Z","timestamp":1341612483000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":12,"title":["A Model of Strain-Dependent Glomerular Basement Membrane Maintenance and Its Potential Ramifications in Health and Disease"],"prefix":"10.1115","volume":"134","author":[{"given":"Victor H.","family":"Barocas","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Dorfman","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Segal","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN 55455; Minneapolis VA Health Care System, Minneapolis, MN 55417"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2012,8,6]]},"reference":[{"issue":"1","key":"2019100412205418500_c1","first-page":"F1","article-title":"Structural Determinants of Glomerular Hydraulic Permeability","volume":"266","author":"Drumond","journal-title":"Am. 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