{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:27:56Z","timestamp":1791300476795,"version":"4.1.0"},"reference-count":60,"publisher":"ASME International","issue":"3","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:p>Central artery stiffness has emerged over the past 15 years as a clinically significant indicator of cardiovascular function and initiator of disease. Loss of elastic fiber integrity is one of the primary contributors to increased arterial stiffening in aging, hypertension, and related conditions. Elastic fibers consist of an elastin core and multiple glycoproteins; hence defects in any of these constituents can adversely affect arterial wall mechanics. In this paper, we focus on mechanical consequences of the loss of fibulin-5, an elastin-associated glycoprotein involved in elastogenesis. Specifically, we compared the biaxial mechanical properties of five central arteries\u2014the ascending thoracic aorta, descending thoracic aorta, suprarenal abdominal aorta, infrarenal abdominal aorta, and common carotid artery\u2014from male and female wild-type and fibulin-5 deficient mice. Results revealed that, independent of sex, all five regions in the fibulin-5 deficient mice manifested a marked increase in structural stiffness but also a marked decrease in elastic energy storage and typically an increase in energy dissipation, with all differences being most dramatic in the ascending and abdominal aortas. Given that the primary function of large arteries is to store elastic energy during systole and to use this energy during diastole to work on the blood, fibulin-5 deficiency results in a widespread diminishment of central artery function that can have significant effects on hemodynamics and cardiac function.<\/jats:p>","DOI":"10.1115\/1.4029431","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T14:30:28Z","timestamp":1419258628000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":95,"title":["Decreased Elastic Energy Storage, Not Increased Material Stiffness, Characterizes Central Artery Dysfunction in Fibulin-5 Deficiency Independent of Sex"],"prefix":"10.1115","volume":"137","author":[{"given":"J.","family":"Ferruzzi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Malone Engineering Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Bersi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Malone Engineering Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Uman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Malone Engineering Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Fellow ASME Department of Biomedical Engineering, Malone Engineering Center, Yale University, New Haven, CT 06520"},{"name":"Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510 e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","reference":[{"issue":"7","key":"2019100601064629600_B1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.biocel.2010.03.009","article-title":"Unraveling the Mechanism of Elastic Fiber Assembly: The Roles of Short Fibulins","volume":"42","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"2019100601064629600_B2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jcp.21189","article-title":"Fibrillin-Rich Microfibrils: Structural Determinants of Morphogenetic and Homeostatic Events","volume":"213","year":"2007","journal-title":"J. Cell. 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