{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:27:21Z","timestamp":1790126841564,"version":"4.0.1"},"reference-count":61,"publisher":"ASME International","issue":"4","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>Intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAA) has potential implications to aneurysm growth and rupture risk; yet, the mechanisms underlying its development remain poorly understood. Some researchers have proposed that ILT development may be driven by biomechanical platelet activation within the AAA, followed by adhesion in regions of low wall shear stress. Studies have investigated wall shear stress levels within AAA, but platelet activation potential (AP) has not been quantified. In this study, patient-specific computational fluid dynamic (CFD) models were used to analyze stress-induced AP within AAA under rest and exercise flow conditions. The analysis was conducted using Lagrangian particle-based and Eulerian continuum-based approaches, and the results were compared. Results indicated that biomechanical platelet activation is unlikely to play a significant role for the conditions considered. No consistent trend was observed in comparing rest and exercise conditions, but the functional dependence of AP on stress magnitude and exposure time can have a large impact on absolute levels of anticipated platelet AP. The Lagrangian method obtained higher peak AP values, although this difference was limited to a small percentage of particles that falls below reported levels of physiologic background platelet activation.<\/jats:p>","DOI":"10.1115\/1.4029580","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T20:30:55Z","timestamp":1421267455000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":57,"title":["Mechanical Platelet Activation Potential in Abdominal Aortic Aneurysms"],"prefix":"10.1115","volume":"137","author":[{"given":"Kirk B.","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of California, 5126 Etcheverry Hall, Berkeley, CA 94720-1740"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Arzani","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of California, 5126 Etcheverry Hall, Berkeley, CA 94720-1740"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn C.","family":"Shadden","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of California, 5126 Etcheverry Hall, Berkeley, CA 94720-1740 e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","reference":[{"issue":"4","key":"2019100601163618700_B1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0741-5214(94)90277-1","article-title":"Computed Tomography Scanning Findings Associated With Rapid Expansion of Abdominal Aortic Aneurysms","volume":"20","year":"1994","journal-title":"J. Vasc. Surg."},{"issue":"5","key":"2019100601163618700_B2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1053\/ejvs.2000.1217","article-title":"Growth of Thrombus May be a Better Predictor of Rupture Than Diameter in Patients With Abdominal Aortic Aneurysms","volume":"20","year":"2000","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"7","key":"2019100601163618700_B3","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s10439-013-0786-6","article-title":"The Role of Geometric and Biomechanical Factors in Abdominal Aortic Aneurysm Rupture Risk Assessment","volume":"41","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"2","key":"2019100601163618700_B4","doi-asserted-by":"crossref","first-page":"021011","DOI":"10.1115\/1.4023437","article-title":"Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms","volume":"135","year":"2013","journal-title":"ASME J. Biomech. Eng."},{"issue":"1","key":"2019100601163618700_B5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02368298","article-title":"Experimental Investigation of Steady Flow in Rigid Models of Abdominal Aortic Aneurysms","volume":"23","year":"1995","journal-title":"Ann. Biomed. Eng."},{"issue":"3","key":"2019100601163618700_B6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1115\/1.2796008","article-title":"Steady Flow in an Aneurysm Model: Correlation Between Fluid Dynamics and Blood Platelet Deposition","volume":"118","year":"1996","journal-title":"ASME J. Biomech. Eng."},{"issue":"12","key":"2019100601163618700_B7","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0021-9290(99)00134-7","article-title":"Model Studies of the Flow in Abdominal Aortic Aneurysms During Resting and Exercise Conditions","volume":"32","year":"1999","journal-title":"J. Biomech."},{"issue":"1","key":"2019100601163618700_B8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s10016-003-0101-3","article-title":"Hemodynamic Changes Occurring During the Progressive Enlargement of Abdominal Aortic Aneurysms","volume":"18","year":"2004","journal-title":"Ann. Vasc. Surg."},{"issue":"6","key":"2019100601163618700_B9","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00348-010-1034-6","article-title":"Experimental Unsteady Flow Study in a Patient-Specific Abdominal Aortic Aneurysm Model","volume":"50","year":"2011","journal-title":"Exp. Fluids"},{"issue":"2","key":"2019100601163618700_B10","first-page":"380","article-title":"Hemodynamics of the Normal Aorta Compared to Fusiform and Saccular Abdominal Aortic Aneurysms With Emphasis on a Potential Thrombus Formation Mechanism","volume":"38","year":"2009","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"2019100601163618700_B11","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1007\/s10439-010-9949-x","article-title":"Quantification of Hemodynamics in Abdominal Aortic Aneurysms During Rest and Exercise Using Magnetic Resonance Imaging and Computational Fluid Dynamics","volume":"38","year":"2010","journal-title":"Ann. Biomed. Eng."},{"issue":"8","key":"2019100601163618700_B12","doi-asserted-by":"crossref","first-page":"081901","DOI":"10.1063\/1.4744984","article-title":"Characterization of the Transport Topology in Patient-Specific Abdominal Aortic Aneurysm Models","volume":"24","year":"2012","journal-title":"Phys. Fluids"},{"issue":"2","key":"2019100601163618700_B13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/cnm.2601","article-title":"Effect of Exercise on Patient Specific Abdominal Aortic Aneurysm Flow Topology and Mixing","volume":"30","year":"2014","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"issue":"63","key":"2019100601163618700_B14","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1098\/rsif.2011.0041","article-title":"Blood Flow and Coherent Vortices in the Normal and Aneurysmatic Aortas: A Fluid Dynamical Approach to Intra-Luminal Thrombus Formation","volume":"8","year":"2011","journal-title":"J. R. Soc. Interface"},{"issue":"7","key":"2019100601163618700_B15","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s10439-011-0285-6","article-title":"A Relation Between Near-Wall Particle-Hemodynamics and Onset of Thrombus Formation in Abdominal Aortic Aneurysms","volume":"39","year":"2011","journal-title":"Ann. Biomed. Eng."},{"issue":"12","key":"2019100601163618700_B16","first-page":"H1786","article-title":"A Longitudinal Comparison of Hemodynamics and Intraluminal Thrombus Deposition in Abdominal Aortic Aneurysms","volume":"307","year":"2014","journal-title":"Am. J. Physiol."},{"issue":"1","key":"2019100601163618700_B17","first-page":"35","article-title":"Response of Human Platelets to Shear Stress","volume":"21","year":"1975","journal-title":"Trans. Am. Soc. Artif. Intern. Organs"},{"issue":"2","key":"2019100601163618700_B18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0021-9290(79)90150-7","article-title":"Shear-Induced Activation of Platelets","volume":"12","year":"1979","journal-title":"J. Biomech."},{"issue":"2","key":"2019100601163618700_B19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-0038-1657744","article-title":"Platelet and Coagulation Parameters Following Millisecond Exposure to Laminar Shear Stress","volume":"54","year":"1985","journal-title":"Thromb. Haemostasis"},{"key":"2019100601163618700_B20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/978-3-642-71787-1_8","article-title":"Studies on the Mechanisms of Shear-Induced Platelet Activation","volume-title":"Cerebral Ischemia and Hemorheology","year":"1987"},{"issue":"5","key":"2019100601163618700_B21","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/039139889001300507","article-title":"Estimation of Shear Stress-Related Blood Damage in Heart Valve Prostheses\u2014In Vitro Comparison of 25 Aortic Valves","volume":"13","year":"1990","journal-title":"Int. J. Artif. Organs"},{"issue":"2","key":"2019100601163618700_B22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF02648048","article-title":"Fluid Mechanics of Arterial Stenosis: Relationship to the Development of Mural Thrombus","volume":"25","year":"1997","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"2019100601163618700_B23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1196\/annals.1302.031","article-title":"Dynamics of Blood Flow and Platelet Transport in Pathological Vessels","volume":"1015","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"2019100601163618700_B24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/MAT.0b013e31815d6898","article-title":"Platelet Activation Due to Hemodynamic Shear Stresses: Damage Accumulation Model and Comparison to In Vitro Measurements","volume":"54","year":"2008","journal-title":"ASAIO J."},{"issue":"5","key":"2019100601163618700_B25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1525-1594.2009.00875.x","article-title":"Computational Fluid Dynamics Analysis of Blade Tip Clearances on Hemodynamic Performance and Blood Damage in a Centrifugal Ventricular Assist Device","volume":"34","year":"2009","journal-title":"Artif. Organs"},{"issue":"2","key":"2019100601163618700_B26","first-page":"897","article-title":"Numerical Investigation of the Effects of Channel Geometry on Platelet Activation and Blood Damage","volume":"39","year":"2010","journal-title":"Ann. Biomed. Eng."},{"issue":"5","key":"2019100601163618700_B27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1525-1594.2004.00015.x","article-title":"The Power-Law Mathematical Model for Blood Damage Prediction: Analytical Developments and Physical Inconsistencies","volume":"28","year":"2004","journal-title":"Artif. Organs"},{"issue":"4","key":"2019100601163618700_B28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10237-005-0005-y","article-title":"A Novel Formulation for Blood Trauma Prediction by a Modified Power-Law Mathematical Model","volume":"4","year":"2005","journal-title":"Biomech. Modell. Mechanobiol."},{"issue":"6","key":"2019100601163618700_B29","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s10237-013-0469-0","article-title":"A Novel Mathematical Model of Activation and Sensitization of Platelets Subjected to Dynamic Stress Histories","volume":"12","year":"2013","journal-title":"Biomech. Modell. Mechanobiol."},{"issue":"6","key":"2019100601163618700_B30","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s10439-013-0758-x","article-title":"Evaluation of Shear-Induced Platelet Activation Models Under Constant and Dynamic Shear Stress Loading Conditions Relevant to Devices","volume":"41","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"10","key":"2019100601163618700_B31","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1046\/j.1525-1594.2003.00026.x","article-title":"Computational Fluid Dynamics Prediction of Blood Damage in a Centrifugal Pump","volume":"27","year":"2003","journal-title":"Artif. Organs"},{"issue":"9","key":"2019100601163618700_B32","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1114\/1.1603257","article-title":"Path-Dependent Hemodynamics of the Stenosed Carotid Bifurcation","volume":"31","year":"2003","journal-title":"Ann. Biomed. Eng."},{"issue":"3","key":"2019100601163618700_B33","first-page":"467","article-title":"Potential Fluid Mechanic Pathways of Platelet Activation","volume":"12","year":"2012","journal-title":"Biomech. Modell. Mechanobiol."},{"issue":"9","key":"2019100601163618700_B34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1046\/j.1525-1594.2002.06954.x","article-title":"Numerical Investigation of the Effect of Blade Geometry on Blood Trauma in a Centrifugal Blood Pump","volume":"26","year":"2002","journal-title":"Artif. Organs"},{"issue":"9","key":"2019100601163618700_B35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1525-1594.2007.00446.x","article-title":"Flow-Induced Platelet Activation and Damage Accumulation in a Mechanical Heart Valve: Numerical Studies","volume":"31","year":"2007","journal-title":"Artif. Organs"},{"issue":"4","key":"2019100601163618700_B36","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1115\/1.2746378","article-title":"Comparison of the Hemodynamic and Thrombogenic Performance of Two Bileaflet Mechanical Heart Valves Using a CFD\/FSI Model","volume":"129","year":"2007","journal-title":"ASME J. Biomech. Eng."},{"issue":"7","key":"2019100601163618700_B37","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1007\/s10439-011-0502-3","article-title":"A Numerical Investigation of Blood Damage in the Hinge Area of Aortic Bileaflet Mechanical Heart Valves During the Leakage Phase","volume":"40","year":"2012","journal-title":"Ann. Biomed. Eng."},{"issue":"11","key":"2019100601163618700_B38","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1007\/s10439-013-0829-z","article-title":"Simulation of Platelets Suspension Flowing Through a Stenosis Model Using a Dissipative Particle Dynamics Approach","volume":"41","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"2019100601163618700_B39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1113\/jphysiol.1963.sp007185","article-title":"The Aggregation of Blood Platelets","volume":"168","year":"1963","journal-title":"J. Physiol."},{"issue":"4","key":"2019100601163618700_B40","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1114\/1.200","article-title":"Computational Simulation of Platelet Deposition and Activation: I. Model Development and Properties","volume":"27","year":"1999","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"2019100601163618700_B41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1114\/1.201","article-title":"Computational Simulation of Platelet Deposition and Activation: II. Results for Poiseuille Flow Over Collagen","volume":"27","year":"1999","journal-title":"Ann. Biomed. Eng."},{"issue":"3\u20134","key":"2019100601163618700_B42","first-page":"183","article-title":"A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood","volume":"5","year":"2003","journal-title":"J. Theor. Med."},{"issue":"1","key":"2019100601163618700_B43","first-page":"47","article-title":"Grow With the Flow: A Spatial\u2013Temporal Model of Platelet Deposition and Blood Coagulation Under Flow","volume":"28","year":"2010","journal-title":"Math. Med. Biol."},{"issue":"8","key":"2019100601163618700_B44","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s11538-012-9784-3","article-title":"The Influence of Hindered Transport on the Development of Platelet Thrombi Under Flow","volume":"75","year":"2013","journal-title":"Bull. Math. Biol."},{"issue":"1","key":"2019100601163618700_B45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1196\/annals.1383.008","article-title":"AAA Disease: Mechanism, Stratification, and Treatment","volume":"1085","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1\u20132","key":"2019100601163618700_B46","first-page":"11","article-title":"Hemodynamic Influences on Abdominal Aortic Aneurysm Disease: Application of Biomechanics to Aneurysm Pathophysiology","volume":"53","year":"2010","journal-title":"Vasc. Pharmacol."},{"issue":"8","key":"2019100601163618700_B47","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1007\/s10439-011-0313-6","article-title":"Hemodynamic Changes Quantified in Abdominal Aortic Aneurysms With Increasing Exercise Intensity Using MR Exercise Imaging and Image-Based Computational Fluid Dynamics","volume":"39","year":"2011","journal-title":"Ann. Biomed. Eng."},{"issue":"1\u20132","key":"2019100601163618700_B48","first-page":"155","article-title":"Finite Element Modeling of Blood Flow in Arteries","volume":"158","year":"1998","journal-title":"Comput. Methods Appl. Mech. Eng."},{"issue":"3\u20134","key":"2019100601163618700_B49","first-page":"305","article-title":"A Generalized-\u03b1 Method for Integrating the Filtered Navier\u2013Stokes Equations With a Stabilized Finite Element Method","volume":"190","year":"2000","journal-title":"Comput. Methods Appl. Mech. Eng."},{"issue":"1","key":"2019100601163618700_B50","first-page":"323","article-title":"Abdominal Aortic Hemodynamic Conditions in Healthy Subjects Aged 50\u201370 at Rest and During Lower Limb Exercise: In Vivo Quantification Using MRI","volume":"168","year":"2003","journal-title":"Atherosclerosis"},{"issue":"5","key":"2019100601163618700_B51","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/01.HYP.12.5.479","article-title":"Altered Hemodynamics During Exercise in Older Essential Hypertensive Subjects","volume":"12","year":"1988","journal-title":"Hypertension"},{"issue":"1","key":"2019100601163618700_B52","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10439-014-1070-0","article-title":"Lagrangian Postprocessing of Computational Hemodynamics","volume":"43","year":"2015","journal-title":"Ann. Biomed. Eng."},{"issue":"2","key":"2019100601163618700_B53","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10558-010-9096-x","article-title":"New Insights Into Pacemaker Lead-Induced Venous Occlusion: Simulation-Based Investigation of Alterations in Venous Biomechanics","volume":"10","year":"2010","journal-title":"Cardiovasc. Eng."},{"issue":"5","key":"2019100601163618700_B54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1525-1594.2001.025005341.x","article-title":"Assessment of Hemolysis Related Quantities in a Microaxial Blood Pump by Computational Fluid Dynamics","volume":"25","year":"2001","journal-title":"Artif. Organs"},{"issue":"11","key":"2019100601163618700_B55","doi-asserted-by":"crossref","first-page":"110802","DOI":"10.1063\/1.4819142","article-title":"A Non-Discrete Method for Computation of Residence Time in Fluid Mechanics Simulations","volume":"25","year":"2013","journal-title":"Phys. Fluids"},{"issue":"3","key":"2019100601163618700_B56","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejvs.2014.05.014","article-title":"Mural Thrombus and the Progression of Abdominal Aortic Aneurysms: A Large Population-Based Prospective Cohort Study","volume":"48","year":"2014","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"7","key":"2019100601163618700_B57","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1007\/s10439-008-9502-3","article-title":"Characterization of Coherent Structures in the Cardiovascular System","volume":"36","year":"2008","journal-title":"Ann. Biomed. Eng."},{"key":"2019100601163618700_B58","article-title":"Lagrangian Coherent Structures","volume-title":"Transport and Mixing in Laminar Flows: From Microfluidics to Oceanic Currents","year":"2011"},{"issue":"4607","key":"2019100601163618700_B59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1126\/science.6574604","article-title":"Inhibitory Role of the Endothelium to the Response of Isolated Coronary Arteries to Platelets","volume":"221","year":"1983","journal-title":"Science"},{"key":"2019100601163618700_B60","first-page":"1","article-title":"Assumptions in Modelling of Large Artery Hemodynamics","volume-title":"Modeling of Physiological Flows","year":"2012"},{"issue":"104","key":"2019100601163618700_B61","first-page":"20140403","article-title":"Synergy Between Shear-Induced Migration and Secondary Flows on Red Blood Cells Transport in Arteries: Considerations on Oxygen Transport","volume":"12","year":"2014","journal-title":"J. R. Soc. Interface"}],"container-title":["Journal of Biomechanical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/doi\/10.1115\/1.4029580\/6091786\/bio_137_04_041005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/doi\/10.1115\/1.4029580\/6091786\/bio_137_04_041005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:52:33Z","timestamp":1598662353000},"score":1,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article\/doi\/10.1115\/1.4029580\/371208\/Mechanical-Platelet-Activation-Potential-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,1]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4,1]]}},"URL":"https:\/\/doi.org\/10.1115\/1.4029580","relation":{},"ISSN":["0148-0731","1528-8951"],"issn-type":[{"value":"0148-0731","type":"print"},{"value":"1528-8951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,1]]},"article-number":"041005"}}