{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:21:52Z","timestamp":1792653712621,"version":"4.5.0"},"reference-count":40,"publisher":"ASME International","issue":"1","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:p>The physiological performance of trachea is highly dependent on its mechanical behavior, and therefore, the mechanical properties of its components. Mechanical characterization of trachea is key to succeed in new treatments such as tissue engineering, which requires the utilization of scaffolds which are mechanically compatible with the native human trachea. In this study, after isolating human trachea samples from brain-dead cases and proper storage, we assessed the viscoelastic properties of tracheal cartilage, smooth muscle, and connective tissue based on stress relaxation tests (at 5% and 10% strains for cartilage and 20%, 30%, and 40% for smooth muscle and connective tissue). After investigation of viscoelastic linearity, constitutive models including Prony series for linear viscoelasticity and quasi-linear viscoelastic, modified superposition, and Schapery models for nonlinear viscoelasticity were fitted to the experimental data to find the best model for each tissue. We also investigated the effect of age on the viscoelastic behavior of tracheal tissues. Based on the results, all three tissues exhibited a (nonsignificant) decrease in relaxation rate with increasing the strain, indicating viscoelastic nonlinearity which was most evident for cartilage and with the least effect for connective tissue. The three-term Prony model was selected for describing the linear viscoelasticity. Among different models, the modified superposition model was best able to capture the relaxation behavior of the three tracheal components. We observed a general (but not significant) stiffening of tracheal cartilage and connective tissue with aging. No change in the stress relaxation percentage with aging was observed. The results of this study may be useful in the design and fabrication of tracheal tissue engineering scaffolds.<\/jats:p>","DOI":"10.1115\/1.4034651","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T16:31:39Z","timestamp":1473697899000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":36,"title":["Viscoelastic Properties of Human Tracheal Tissues"],"prefix":"10.1115","volume":"139","author":[{"given":"Farzaneh","family":"Safshekan","sequence":"first","affiliation":[{"name":"Faculty of Biomedical Engineering, Amirkabir University of Technology, 424 Hafez Avenue, Tehran 15875-4413, Iran e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Tafazzoli-Shadpour","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Amirkabir University of Technology, 424 Hafez Avenue, Tehran 15875-4413, Iran e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Abdouss","sequence":"additional","affiliation":[{"name":"Chemistry Department, Amirkabir University of Technology, 424 Hafez Avenue, Tehran 15875-4413, Iran e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad B.","family":"Shadmehr","sequence":"additional","affiliation":[{"name":"Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Darabad Avenue, Shahid Bahonar Roundabout, Tehran 19558-41452, Iran e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"issue":"1","key":"2019100315231128800_bib1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0003-4975(89)90227-0","article-title":"Notes on the Windpipe","volume":"47","year":"1989","journal-title":"Ann. 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