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Valvular pathologies, such as aortic regurgitation and aortic stenosis, are associated with BAVs, thereby increasing the need for a better understanding of BAV kinematics and geometrical characteristics. The aim of this study is to investigate the influence of the nonfused cusp (NFC) angle in BAV type-1 configuration on the valve's structural and hemodynamic performance. Toward that goal, a parametric fluid\u2013structure interaction (FSI) modeling approach of BAVs is presented. Four FSI models were generated with varying NFC angles between 120\u2009deg and 180\u2009deg. The FSI simulations were based on fully coupled structural and fluid dynamic solvers and corresponded to physiologic values, including the anisotropic hyper-elastic behavior of the tissue. The simulated angles led to different mechanical behavior, such as eccentric jet flow direction with a wider opening shape that was found for the smaller NFC angles, while a narrower opening orifice followed by increased jet flow velocity was observed for the larger NFC angles. Smaller NFC angles led to higher concentrated flow shear stress (FSS) on the NFC during peak systole, while higher maximal principal stresses were found in the raphe region during diastole. The proposed biomechanical models could explain the early failure of BAVs with decreased NFC angles, and suggests that a larger NFC angle is preferable in suture annuloplasty BAV repair surgery.<\/jats:p>","DOI":"10.1115\/1.4038329","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T13:29:21Z","timestamp":1509629361000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":34,"title":["Fluid\u2013Structure Interaction Models of Bicuspid Aortic Valves: The Effects of Nonfused Cusp Angles"],"prefix":"10.1115","volume":"140","author":[{"given":"Karin","family":"Lavon","sequence":"first","affiliation":[{"name":"Faculty of Engineering, School of Mechanical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotem","family":"Halevi","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, School of Mechanical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Marom","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department, Stony Brook University, Stony Brook, NY 11794"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagit","family":"Ben Zekry","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rabin Medical Center, Petach Tikva 4941492, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Joachim Sch\u00e4fers","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospitals of Saarland, Homburg 66421, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Raanani","sequence":"additional","affiliation":[{"name":"Department of Cardio-thoracic Surgery, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Haj-Ali","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"issue":"9","key":"2019100602472638400_bib1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cpcardiol.2005.06.002","article-title":"The Bicuspid Aortic Valve","volume":"30","year":"2005","journal-title":"Curr. 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