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Shell elements were used to model cortical bone, while truss elements were used to model trabecular bone and the ligaments and joints. The finite element (FE) model was subjected to an iterative optimization process based on a strain-driven bone adaptation algorithm. The bone model was adapted to a number of common daily living activities (walking, stair ascent, stair descent, sit-to-stand, and stand-to-sit) by applying onto it joint and muscle loads derived using a musculoskeletal modeling framework. The cortical thickness distribution and the trabecular architecture of the adapted model were compared qualitatively with computed tomography (CT) scans and models developed in previous studies, showing good agreement. The sensitivity of the model to changes in material properties of the ligaments and joint cartilage and changes in parameters related to the adaptation algorithm was assessed. Changes to the target strain had the largest effect on predicted total bone volumes. The model showed low sensitivity to changes in all other parameters. The minimum and maximum principal strains predicted by the structural model compared to a continuum CT-derived model in response to a common test loading scenario showed good agreement with correlation coefficients of 0.813 and 0.809, respectively. The developed structural model enables a number of applications such as fracture modeling, design, and additive manufacturing of frangible surrogates.<\/jats:p>","DOI":"10.1115\/1.4039894","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T22:33:35Z","timestamp":1527287615000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":22,"title":["Pelvic Construct Prediction of Trabecular and Cortical Bone Structural Architecture"],"prefix":"10.1115","volume":"140","author":[{"given":"Dan T.","family":"Zaharie","sequence":"first","affiliation":[{"name":"The Royal British Legion Centre for Blast Injury Studies, Imperial College London, London SW7 2AZ, UK;"},{"name":"Structural Biomechanics, Department of Civil and Environmental Engineering, Imperial College London, Skempton Building, South Kensington Campus, London SW7 2AZ, UK e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T. 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