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Although biomechanics likely contributes to axonal injury within the optic nerve head (ONH), leading to RGC death, the pathways by which this occurs are not well understood. While rat models of glaucoma are well-suited for mechanistic studies, the anatomy of the rat ONH is different from the human, and the resulting differences in biomechanics have not been characterized. The aim of this study is to describe a methodology for building individual-specific finite element (FE) models of rat ONHs. This method was used to build three rat ONH FE models and compute the biomechanical environment within these ONHs. Initial results show that rat ONH strains are larger and more asymmetric than those seen in human ONH modeling studies. This method provides a framework for building additional models of normotensive and glaucomatous rat ONHs. Comparing model strain patterns with patterns of cellular response seen in studies using rat glaucoma models will help us to learn more about the link between biomechanics and glaucomatous cell death, which in turn may drive the development of novel therapies for glaucoma.<\/jats:p>","DOI":"10.1115\/1.4039998","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T07:47:05Z","timestamp":1531468025000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":13,"title":["A Methodology for Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma"],"prefix":"10.1115","volume":"140","author":[{"given":"Stephen A.","family":"Schwaner","sequence":"first","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, 2306 IBB, Atlanta, GA 30332 e-mail:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Kight","sequence":"additional","affiliation":[{"name":"Coulter Department of Biomedical Engineering, Georgia Institute of Technology\/Emory University, Atlanta, GA 30332 e-mail:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Perry","sequence":"additional","affiliation":[{"name":"Coulter Department of Biomedical Engineering, Georgia Institute of Technology\/Emory University, Atlanta, GA 30332 e-mail:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Pazos","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic d'Oftalmologia, Hospital Cl\u00ednic de Barcelona, Barcelona 08036, Spain e-mail:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Yang","sequence":"additional","affiliation":[{"name":"Optic Nerve Head Research Laboratory, Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, OR 97210 e-mail:"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"The Kenneth C. 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