{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:47:17Z","timestamp":1790203637194,"version":"4.1.0"},"reference-count":56,"publisher":"ASME International","issue":"10","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15POST25910002"],"award-info":[{"award-number":["15POST25910002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL104080"],"award-info":[{"award-number":["HL104080"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL127570"],"award-info":[{"award-number":["HL127570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p>Paravalvular leak (PVL) is a relatively frequent complication after transcatheter aortic valve replacement (TAVR) with increased mortality. Currently, there is no effective method to pre-operatively predict and prevent PVL. In this study, we developed a computational model to predict the severity of PVL after TAVR. Nonlinear finite element (FE) method was used to simulate a self-expandable CoreValve deployment into a patient-specific aortic root, specified with human material properties of aortic tissues. Subsequently, computational fluid dynamics (CFD) simulations were performed using the post-TAVR geometries from the FE simulation, and a parametric investigation of the impact of the transcatheter aortic valve (TAV) skirt shape, TAV orientation, and deployment height on PVL was conducted. The predicted PVL was in good agreement with the echocardiography data. Due to the scallop shape of CoreValve skirt, the difference of PVL due to TAV orientation can be as large as 40%. Although the stent thickness is small compared to the aortic annulus size, we found that inappropriate modeling of it can lead to an underestimation of PVL up to 10\u2009ml\/beat. Moreover, the deployment height could significantly alter the extent and the distribution of regurgitant jets, which results in a change of leaking volume up to 70%. Further investigation in a large cohort of patients is warranted to verify the accuracy of our model. This study demonstrated that a rigorously developed patient-specific computational model can provide useful insights into underlying mechanisms causing PVL and potentially assist in pre-operative planning for TAVR to minimize PVL.<\/jats:p>","DOI":"10.1115\/1.4040457","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T20:28:37Z","timestamp":1532118517000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":56,"title":["Numerical Parametric Study of Paravalvular Leak Following a Transcatheter Aortic Valve Deployment Into a Patient-Specific Aortic Root"],"prefix":"10.1115","volume":"140","author":[{"given":"Wenbin","family":"Mao","sequence":"first","affiliation":[{"name":"Tissue Mechanics Laboratory,The Wallace H. Coulter Departmentof Biomedical Engineering,Georgia Institute of Technologyand Emory University,Atlanta, GA 30313-2412"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Tissue Mechanics Laboratory,The Wallace H. Coulter Departmentof Biomedical Engineering,Georgia Institute of Technologyand Emory University,Atlanta, GA 30313-2412"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel","family":"Kodali","sequence":"additional","affiliation":[{"name":"Division of Cardiology,Columbia University Medical Center,New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Tissue Mechanics Laboratory,The Wallace H. Coulter Departmentof Biomedical Engineering,Georgia Institute of Technologyand Emory University,206 Technology Enterprise Park,Georgia Institute of Technology,387 Technology Circle,Atlanta, GA 30313-2412e-mail:\u2002wei.sun@bme.gatech.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"issue":"6","key":"2026041418414029300_bib1","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/CIRCULATIONAHA.105.582882","article-title":"Percutaneous Aortic Valve Implantation Retrograde From the Femoral Artery","volume":"113","year":"2006","journal-title":"Circulation"},{"issue":"17","key":"2026041418414029300_bib2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery","volume":"363","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"2026041418414029300_bib3","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter Versus Surgical Aortic-Valve Replacement in High-Risk Patients","volume":"364","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"2026041418414029300_bib4","doi-asserted-by":"publisher","first-page":"e201632","DOI":"10.21542\/gcsp.2016.32","article-title":"The Development of Transcatheter Aortic Valve Replacement (TAVR)","volume":"2016","year":"2017","journal-title":"Global Cardiol. Sci. Pract."},{"issue":"20","key":"2026041418414029300_bib5","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1016\/j.jacc.2015.03.014","article-title":"Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Valve Stenosis: 1-Year Results From the All-Comers NOTION Randomized Clinical Trial","volume":"65","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"2026041418414029300_bib6","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.jacc.2012.08.1039","article-title":"Paravalvular Leak After Transcatheter Aortic Valve Replacement: The New Achilles' Heel? A Comprehensive Review Literature","volume":"61","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"17","key":"2026041418414029300_bib7","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients","volume":"374","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"2026041418414029300_bib8","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1056\/NEJMoa1200384","article-title":"Two-Year Outcomes After Transcatheter or Surgical Aortic-Valve Replacement","volume":"366","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"2026041418414029300_bib9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.pcad.2014.03.004","article-title":"Challenges and Future Opportunities for Transcatheter Aortic Valve Therapy","volume":"56","year":"2014","journal-title":"Prog. Cardiovasc. Dis."},{"key":"2026041418414029300_bib10","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev177","article-title":"Value of CMR in Quantification of Paravalvular Aortic Regurgitation After TAVI","volume":"17","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"11","key":"2026041418414029300_bib11","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.crad.2016.07.016","article-title":"Paravalvular Leak After Transcatheter Aortic Valve Implantation: Is It Anatomically Predictable or Procedurally Determined? MDCT Study","volume":"71","year":"2016","journal-title":"Clin. Radiol."},{"issue":"15","key":"2026041418414029300_bib12","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.jacc.2012.09.001","article-title":"Updated Standardized Endpoint Definitions for Transcatheter Aortic Valve Implantation: The Valve Academic Research Consortium-2 Consensus Document","volume":"60","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"2026041418414029300_bib13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12947-016-0080-5","article-title":"Limitations and Difficulties of Echocardiographic Short-Axis Assessment of Paravalvular Leakage After Corevalve Transcatheter Aortic Valve Implantation","volume":"14","year":"2016","journal-title":"Cardiovasc. Ultrasound"},{"issue":"3","key":"2026041418414029300_bib14","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jcmg.2015.01.008","article-title":"Assessment of Paravalvular Regurgitation Following TAVR: A Proposal of Unifying Grading Scheme","volume":"8","year":"2015","journal-title":"JACC: Cardiovasc. Imaging"},{"issue":"12","key":"2026041418414029300_bib15","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1080\/10255842.2012.746676","article-title":"Simulation of Transcatheter Aortic Valve Implantation: A Patient-Specific Finite Element Approach","volume":"17","year":"2013","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"issue":"2","key":"2026041418414029300_bib16","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11517-012-0864-1","article-title":"Patient-Specific Simulations of Transcatheter Aortic Valve Stent Implantation","volume":"50","year":"2012","journal-title":"Med. Biol. Eng. Comput."},{"issue":"9","key":"2026041418414029300_bib17","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1007\/s10439-014-1051-3","article-title":"Simulation of Self Expanding Transcatheter Aortic Valve in a Realistic Aortic Root: Implications of Deployment Geometry on Leaflet Deformation","volume":"42","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"2026041418414029300_bib18","doi-asserted-by":"crossref","unstructured":"Russ, C., Hopf, R., Hirsch, S., Sundermann, S., Falk, V., Szekely, G., and Gessat, M., 2013, \u201cSimulation of Transcatheter Aortic Valve Implantation Under Consideration of Leaflet Calcification,\u201d 35th Annual International Conference of the Engineering in Medicine and Biology Society(EMBC), Osaka, Japan, July 3\u20137, pp. 711\u2013714.10.1109\/EMBC.2013.6609599","DOI":"10.1109\/EMBC.2013.6609599"},{"issue":"11","key":"2026041418414029300_bib19","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.jbiomech.2012.05.008","article-title":"Patient-Specific Modeling of Biomechanical Interaction in Transcatheter Aortic Valve Deployment","volume":"45","year":"2012","journal-title":"J. Biomech."},{"issue":"5","key":"2026041418414029300_bib20","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.jcin.2016.01.003","article-title":"Patient-Specific Computer Modeling to Predict Aortic Regurgitation After Transcatheter Aortic Valve Replacement","volume":"9","year":"2016","journal-title":"JACC: Cardiovasc. Interventions"},{"issue":"2","key":"2026041418414029300_bib21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s12471-016-0923-6","article-title":"Patient-Specific Computer Modelling\u2013Its Role in the Planning of Transcatheter Aortic Valve Implantation","volume":"25","year":"2017","journal-title":"Netherlands Heart J."},{"key":"2026041418414029300_bib22","article-title":"Energetic and Hemodynamic Characteristics of Paravalvular Leak Following Transcatheter Aortic Valve Replacement","year":"2015","journal-title":"Masters thesis"},{"issue":"13","key":"2026041418414029300_bib23","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1016\/j.jbiomech.2016.06.024","article-title":"A Validated Methodology for Patient Specific Computational Modeling of Self-Expandable Transcatheter Aortic Valve Implantation","volume":"49","year":"2016","journal-title":"J. Biomech."},{"key":"2026041418414029300_bib24","doi-asserted-by":"crossref","unstructured":"Gessat, M., Altwegg, L., Frauenfelder, T., Plass, A., and Falk, V., 2011, \u201cCubic Hermite Bezier Spline Based Reconstruction of Implanted Aortic Valve Stents From CT Images,\u201d Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Boston, MA, Aug. 30\u2013Sept. 3, pp. 2667\u20132670.10.1109\/IEMBS.2011.6090733","DOI":"10.1109\/IEMBS.2011.6090733"},{"issue":"1\u20133","key":"2026041418414029300_bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1010835316564","article-title":"A New Constitutive Framework for Arterial Wall Mechanics and a Comparative Study of Material Models","volume":"61","year":"2000","journal-title":"J. Elasticity Phys. Sci. Solids"},{"issue":"6","key":"2026041418414029300_bib26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1098\/rsif.2005.0073","article-title":"Hyperelastic Modelling of Arterial Layers With Distributed Collagen Fibre Orientations","volume":"3","year":"2006","journal-title":"J. R. Soc. Interface"},{"issue":"8","key":"2026041418414029300_bib27","doi-asserted-by":"publisher","first-page":"081007","DOI":"10.1115\/1.4036829","article-title":"Numerical Approximation of Elasticity Tensor Associated With Green-Naghdi Rate","volume":"139","year":"2017","journal-title":"ASME J. Biomech. Eng."},{"issue":"11","key":"2026041418414029300_bib28","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1080\/10255842.2015.1118467","article-title":"Computational Efficiency of Numerical Approximations of Tangent Moduli for Finite Element Implementation of a Fiber-Reinforced Hyperelastic Material Model","volume":"19","year":"2016","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"issue":"6","key":"2026041418414029300_bib29","doi-asserted-by":"publisher","first-page":"061003","DOI":"10.1115\/1.2979872","article-title":"Numerical Approximation of Tangent Moduli for Finite Element Implementations of Nonlinear Hyperelastic Material Models","volume":"130","year":"2008","journal-title":"ASME J. Biomech. Eng."},{"issue":"1567","key":"2026041418414029300_bib30","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1098\/rspa.1972.0026","article-title":"Large Deformation Isotropic Elasticity-on the Correlation of Theory and Experiment for Incompressible Rubberlike Solids","volume":"326","year":"1972","journal-title":"Proc. R. Soc. London A: Math., Phys. Eng. Sci., R. Soc."},{"issue":"5","key":"2026041418414029300_bib31","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1115\/1.1800557","article-title":"Anisotropic Mechanical Properties of Tissue Components in Human Atherosclerotic Plaques","volume":"126","year":"2004","journal-title":"ASME J. Biomech. Eng."},{"issue":"1","key":"2026041418414029300_bib32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10237-014-0583-7","article-title":"Simulations of Transcatheter Aortic Valve Implantation: Implications for Aortic Root Rupture","volume":"14","year":"2015","journal-title":"Biomech. Modeling Mechanobiol."},{"issue":"1","key":"2026041418414029300_bib33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ejcts.2010.08.056","article-title":"Significant Differences in the Material Properties Between Aged Human and Porcine Aortic Tissues","volume":"40","year":"2011","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"issue":"1","key":"2026041418414029300_bib34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.medengphy.2012.04.009","article-title":"Numerical Analysis of the Radial Force Produced by the Medtronic-CoreValve and Edwards-SAPIEN after Transcatheter Aortic Valve Implantation (TAVI)","volume":"35","year":"2013","journal-title":"Med. Eng. Phys."},{"issue":"3","key":"2026041418414029300_bib35","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s10439-012-0694-1","article-title":"Quantification of Biomechanical Interaction of Transcatheter Aortic Valve Stent Deployed in Porcine and Ovine Hearts","volume":"41","year":"2013","journal-title":"Ann. Biomed. Eng."},{"issue":"10","key":"2026041418414029300_bib36","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jacc.2009.04.075","article-title":"Geometry and Degree of Apposition of the CoreValve ReValving System With Multislice Computed Tomography After Implantation in Patients With Aortic Stenosis","volume":"54","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"2026041418414029300_bib37","article-title":"STAR-CCM+ User Guide, Version 10.02","author":"CD-Adapco","year":"2015"},{"issue":"2","key":"2026041418414029300_bib38","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1006\/jtbi.1999.0953","article-title":"Aspects of Fluid Dynamics Applied to the Larger Arteries","volume":"199","year":"1999","journal-title":"J. Theor. Biol."},{"issue":"6","key":"2026041418414029300_bib39","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/aor.12589","article-title":"Development of an In Vivo Model to Characterize the Effects of Transcatheter Aortic Valve on Coronary Artery Flow","volume":"40","year":"2016","journal-title":"Artif. Organs"},{"issue":"15","key":"2026041418414029300_bib40","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1161\/CIRCULATIONAHA.106.639450","article-title":"Percutaneous Implantation of the CoreValve Self-Expanding Valve Prosthesis in High-Risk Patients With Aortic Valve Disease","volume":"114","year":"2006","journal-title":"Circulation"},{"issue":"4","key":"2026041418414029300_bib41","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1088\/0967-3334\/25\/4\/009","article-title":"A Physiologically Representative In Vitro Model of the Coronary Circulation","volume":"25","year":"2004","journal-title":"Physiol. Meas."},{"issue":"4","key":"2026041418414029300_bib42","doi-asserted-by":"publisher","first-page":"044502","DOI":"10.1115\/1.4000990","article-title":"In Vitro Investigation of the Impact of Aortic Valve Stenosis Severity on Left Coronary Artery Flow","volume":"132","year":"2010","journal-title":"ASME J. Biomech. Eng."},{"issue":"3","key":"2026041418414029300_bib43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/ejechocard\/jeq030","article-title":"European Association of Echocardiography Recommendations for the Assessment of Valvular Regurgitation\u2014Part 1: Aortic and Pulmonary Regurgitation (Native Valve Disease)","volume":"11","year":"2010","journal-title":"Eur. J. Echocardiography"},{"issue":"2","key":"2026041418414029300_bib44","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/0735-1097(94)90432-4","article-title":"Effective Regurgitant Orifice Area: A Noninvasive Doppler Development of an Old Hemodynamic Concept","volume":"23","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"2026041418414029300_bib45","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.amjcard.2011.07.007","article-title":"Location and Severity of Aortic Valve Calcium and Implications for Aortic Regurgitation After Transcatheter Aortic Valve Implantation","volume":"108","year":"2011","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"2026041418414029300_bib46","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ijcard.2010.03.004","article-title":"Association of Aortic Valve Calcification Severity With the Degree of Aortic Regurgitation After Transcatheter Aortic Valve Implantation","volume":"150","year":"2011","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"2026041418414029300_bib47","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.echo.2014.11.013","article-title":"Impact of Device Landing Zone Calcification on Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement: A Real-Time Three-Dimensional Transesophageal Echocardiographic Study","volume":"28","year":"2015","journal-title":"J. Am. Soc. Echocardiography"},{"issue":"5","key":"2026041418414029300_bib48","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s10554-013-0197-7","article-title":"CT Predictors of Post-Procedural Aortic Regurgitation in Patients Referred for Transcatheter Aortic Valve Implantation: An Analysis of 105 Patients","volume":"29","year":"2013","journal-title":"Int. J. Cardiovasc. Imaging"},{"issue":"16","key":"2026041418414029300_bib49","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1016\/j.jbiomech.2010.08.010","article-title":"Simulated Elliptical Bioprosthetic Valve Deformation: Implications for Asymmetric Transcatheter Valve Deployment","volume":"43","year":"2010","journal-title":"J. Biomech."},{"key":"2026041418414029300_bib50","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.4244\/EIJV9SSA18","article-title":"Medtronic CoreValve Evolut R with EnVeo R","volume":"9","year":"2013","journal-title":"EuroIntervention"},{"issue":"3","key":"2026041418414029300_bib51","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jcin.2012.09.019","article-title":"Transcatheter Aortic Valve Replacement With the SAPIEN 3: A New Balloon-Expandable Transcatheter Heart Valve","volume":"6","year":"2013","journal-title":"JACC: Cardiovasc. Interventions"},{"issue":"1","key":"2026041418414029300_bib52","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/joic.12165","article-title":"How to Adapt the Implantation Technique for the New SAPIEN 3 Transcatheter Heart Valve Design","volume":"28","year":"2015","journal-title":"J. Interventional Cardiol."},{"key":"2026041418414029300_bib53","volume-title":"Transport Phenomena","year":"2007"},{"key":"2026041418414029300_bib54","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jmbbm.2017.08.039","article-title":"Characterization of Mechanical Properties of Pericardium Tissue Using Planar Biaxial Tension and Flexural Deformation","volume":"77","year":"2018","journal-title":"J. Mechanical Behavior Biomedical Materials"},{"key":"2026041418414029300_bib55","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1146\/annurev-fluid-122414-034314","article-title":"Fluid Mechanics of Heart Valves and Their Replacements","volume":"48","year":"2016","journal-title":"Annu. Rev. Fluid Mech."},{"issue":"4","key":"2026041418414029300_bib56","first-page":"197","article-title":"A Critical Review on Blood Flow in Large Arteries; Relevance to Blood Rheology, Viscosity Models, and Physiologic Conditions","volume":"20","year":"2008","journal-title":"Korea-Australia Rheol. J."}],"container-title":["Journal of Biomechanical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/140\/10\/101007\/6097585\/bio_140_10_101007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/140\/10\/101007\/6097585\/bio_140_10_101007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:41:49Z","timestamp":1776206509000},"score":1,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article\/140\/10\/101007\/367659\/Numerical-Parametric-Study-of-Paravalvular-Leak"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1115\/1.4040457","relation":{},"ISSN":["0148-0731","1528-8951"],"issn-type":[{"value":"0148-0731","type":"print"},{"value":"1528-8951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]},"article-number":"101007"}}