{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:08:24Z","timestamp":1773180504648,"version":"3.50.1"},"reference-count":35,"publisher":"ASME International","issue":"4","funder":[{"name":"MedBlue","award":["MedBlue Translational Grant"],"award-info":[{"award-number":["MedBlue Translational Grant"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 R41 GM117657-01"],"award-info":[{"award-number":["1 R41 GM117657-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"NC Biotechnology Center","doi-asserted-by":"publisher","award":["NC Biotechnology Center Technology Enhancement Grant"],"award-info":[{"award-number":["NC Biotechnology Center Technology Enhancement Grant"]}],"id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>One opportunity to reduce hernia occurrence and recurrence rates (currently estimated to be 30% at 10\u2009years postoperatively) is by enhancing the ability of hernia meshes to anchor into tissue to prevent mesh migration, mesh contraction, and mesh tearing away from tissue. To address this, we developed a novel moderate-weight, macroporous, polypropylene mesh (termed the T-line mesh) with mesh extensions to optimize anchoring. We examined the physical properties, biomechanical performance, and biocompatibility of this novel mesh versus a predicate mesh anchored with #0-suture. The physical properties of the T-line mesh and predicate mesh were measured using American Society for Testing and Materials (ASTM) standards. Meshes were implanted into a swine hernia model and harvested after one day to determine anchoring strength of the meshes in the perioperative period. A separate group was implanted into a swine hernia model and harvested at 30\u2009days and 90\u2009days for semiquantitative histological analysis of biocompatibility. T-line mesh physical properties were similar to commonly used moderate-weight meshes in thickness and areal density. The T-line mesh outperformed the predicate mesh in all mechanical testing (P\u2009&lt;\u20090.05). In the perioperative period, the T-line mesh was \u223c275% stronger (P\u2009&lt;\u20090.001) than the standard of care. Histological analysis of biocompatibility demonstrated no significant difference between the T-line mesh and predicate mesh (P\u2009&gt;\u20090.05). The T-line mesh is a novel hernia mesh that outperforms a predicate mesh in mechanical and biomechanical performance testing while exhibiting similar biocompatibility. The T-line mesh has the potential to reduce hernia occurrence and recurrence caused by mechanical failure.<\/jats:p>","DOI":"10.1115\/1.4043740","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T11:33:33Z","timestamp":1557488013000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":7,"title":["Soft Tissue Anchoring Performance, Biomechanical Properties, and Tissue Reaction of a New Hernia Mesh Engineered to Address Hernia Occurrence and Recurrence"],"prefix":"10.1115","volume":"13","author":[{"given":"Mohamad M.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Division of Plastic, Maxillofacial, and Oral Surgery, Department of Surgery, Duke University Medical Center, DUMC 3181, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Green","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, 487 Medical Science Research Building 1, 203 Research Drive, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Everitt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ruppert","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Glisson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Leopardi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Risoli","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maragatha","family":"Kuchibhatla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Division of Lab Animal Resources (DLAR), Duke University School of Medicine, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Levinson","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"issue":"4","key":"2019110505433475200_bib1","first-page":"185","article-title":"The Results of Incisional Hernia Repair: A Twelve Year Review","volume":"68","year":"1986","journal-title":"Ann. 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