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A physiological simulation system was designed to analyze the trajectory patterns of bovine embolus analogs (EAs) (n\u2009=\u2009720) through four patient-specific models, under three flow conditions: steady flow, normal pulsatile flow, and AF pulsatile flow. It was seen that EA trajectory paths were proportional to the percentage flowrate split of 25\u201331% along the branching vessels. Overall, AF flow conditions increased trajectories through the left- (LCCA) and right (RCCA)-common carotid artery by 25% with respect to normal pulsatile flow. There was no statistical difference in the distribution of clot trajectories when the clot was released from the right, left, or anterior positions. Significantly, more EAs traveled through the brachiocephalic trunk (BCT) than through the LCCA or the left subclavian. Yet of the EAs that traveled through the common carotid arteries, there was a greater affiliation toward the LCCA compared to the RCCA (p\u2009&lt;\u20090.05).<\/jats:p>","DOI":"10.1115\/1.4043832","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T12:55:43Z","timestamp":1558529743000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":18,"title":["Embolus Analog Trajectory Paths Under Physiological Flowrates Through Patient-Specific Aortic Arch Models"],"prefix":"10.1115","volume":"141","author":[{"given":"F.","family":"Malone","sequence":"first","affiliation":[{"name":"GMedTech, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway H91 T8NW, Ireland e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"GMedTech, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway H91 T8NW, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Delassus","sequence":"additional","affiliation":[{"name":"GMedTech, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway H91 T8NW, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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