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However, adverse surgical outcomes of contemporary lumbar TDAs have been reported. We previously proposed a new mobile-bearing AD design concept featuring a biconcave ultrahigh-molecular-weight polyethylene (UHMWPE) mobile core. The objective of this study was to develop an artificial neural network (NN) based multiobjective optimization framework to refine the biconcave-core AD design considering multiple TDA performance metrics, simultaneously. We hypothesized that there is a tradeoff relationship between the performance metrics in terms of range of motion (ROM), facet joint force (FJF), and polyethylene contact pressure (PCP). By searching the resulting three-dimensional (3D) Pareto frontier after multiobjective optimization, it was found that there was a \u201cbest-tradeoff\u201d AD design, which could balance all the three metrics, without excessively sacrificing each metric. However, for each single-objective optimum AD design, only one metric was optimal, and distinct sacrifices were observed in the other two metrics. For a commercially available biconvex-core AD design, the metrics were even worse than the poorest outcomes of the single-objective optimum AD designs. Therefore, multiobjective design optimization could be useful for achieving native lumbar segment biomechanics and minimal PCPs, as well as for improving the existing lumbar motion-preserving surgical treatments.<\/jats:p>","DOI":"10.1115\/1.4045048","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T13:08:38Z","timestamp":1569935318000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":13,"title":["Multiobjective Design Optimization of a Biconcave Mobile-Bearing Lumbar Total Artificial Disk Considering Spinal Kinematics, Facet Joint Loading, and Metal-on-Polyethylene Contact Mechanics"],"prefix":"10.1115","volume":"142","author":[{"given":"Chaochao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, NY 13902-6000"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Willing","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, NY 13902-6000; Department of Mechanical and Materials Engineering, Western University, Thompson Engineering Building, Room TEB 363, London, ON N6A 5B9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"issue":"12","key":"2019121210430706800_bib1","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s00586-008-0811-x","article-title":"Design Concepts in Lumbar Total Disc Arthroplasty","volume":"17","year":"2008","journal-title":"Eur. 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