{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:37:26Z","timestamp":1790728646312,"version":"4.1.0"},"reference-count":86,"publisher":"ASME International","issue":"5","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There is much debate in the literature surrounding the effects of heart rate on aortic regurgitation (AR). Despite the contradictory information, it is still widely believed that an increase in heart rate is beneficial due to the disproportionate shortening of the duration of diastole relative to systole, permitting less time for the left ventricle to fill from regurgitation. This in vitro work investigates how a change in heart rate affects the left ventricular fluid dynamics in the absence and presence of acute AR. The experiments are performed on a novel double-activation left heart simulator previously used for the study of chronic AR. The intraventricular velocity fields are acquired via time-resolved planar particle image velocimetry (PIV) in a clinically relevant plane. Considering fluid dynamic factors, an increase in heart rate was observed to have a limited benefit in the case of mild AR and a detrimental effect for more severe AR. With increasing heart rate, mild AR was associated with a decrease in regurgitant volume, a negligible change in regurgitant volume per diastolic second, and a limited reduction in the fraction of retained regurgitant inflow. More severe AR was accompanied by an increase in both regurgitant volume and the fraction of retained regurgitant inflow, implying a less effective pumping efficiency and a longer relative residence time of blood in the ventricle. Globally, the left ventricle's capacity to compensate for the increase in energy dissipation associated with an increase in heart rate diminishes considerably with severity, a phenomenon which may be exploited further as a method of noninvasive assessment of the severity of AR. These findings may affect the clinical belief that tachycardia is preferred in acute AR and should be investigated further in the clinical setting.<\/jats:p>","DOI":"10.1115\/1.4045400","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T11:51:28Z","timestamp":1573213888000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":5,"title":["Experimental Investigation of the Effect of Heart Rate on Flow in the Left Ventricle in Health and Disease\u2014Aortic Valve Regurgitation"],"prefix":"10.1115","volume":"142","author":[{"given":"Giuseppe","family":"Di Labbio","sequence":"first","affiliation":[{"name":"Department of Mechanical, Industrial & Aerospace Engineering, Concordia University, 1455 Blvd. De Maisonneuve W., Montr\u00e9al, QC H3G 1M8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Ben Assa","sequence":"additional","affiliation":[{"name":"Cardiology Division, Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv 6997801, Israel; Institute for Medical Engineering and Science, Massachusetts Institute of Technology,77 Massachusetts Avenue, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyes","family":"Kadem","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Industrial & Aerospace Engineering, Concordia University, 1455 Blvd. De Maisonneuve W., Montr\u00e9al, QC H3G 1M8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"issue":"3","key":"2020012009493795600_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrcardio.2010.202","article-title":"Epidemiology of Valvular Heart Disease in the Adult","volume":"8","year":"2011","journal-title":"Nat. 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Technol."},{"key":"2020012009493795600_bib49","volume-title":"Particle Image Velocimetry: A Practical Guide","year":"2007"},{"issue":"6","key":"2020012009493795600_bib50","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s00348-005-0037-1","article-title":"Improvements on the Accuracy of Derivative Estimation From DPIV Velocity Measurements","volume":"39","year":"2005","journal-title":"Exp. Fluids"},{"issue":"1","key":"2020012009493795600_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s13239-015-0251-9","article-title":"Time-Resolved Particle Image Velocimetry Measurements With Wall Shear Stress and Uncertainty Quantification for the FDA Nozzle Model","volume":"7","year":"2016","journal-title":"Cardiovasc. Eng. 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Eng."},{"key":"2020012009493795600_bib55","first-page":"25","article-title":"Identification of Vortical Structures by a Non-Local Criterion: Application to PIV Measurements and DNS-LES Results of Turbulent Rotating Flows","year":"1997"},{"issue":"9","key":"2020012009493795600_bib56","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1088\/0957-0233\/12\/9\/307","article-title":"Combining PIV, POD and Vortex Identification Algorithms for the Study of Unsteady Turbulent Swirling Flows","volume":"12","year":"2001","journal-title":"Meas. Sci. Technol."},{"issue":"4","key":"2020012009493795600_bib57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/bjsm.2004.013037","article-title":"A Review of the Stroke Volume Response to Upright Exercise in Healthy Subjects","volume":"39","year":"2005","journal-title":"Brit. J. Sport. 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