{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:16:32Z","timestamp":1762607792568,"version":"3.41.2"},"reference-count":37,"publisher":"ASME International","issue":"8","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mild traumatic brain injuries are typically caused by nonpenetrating head impacts that accelerate the skull and result in deformation of the brain within the skull. The shear and compressive strains caused by these deformations damage neural and vascular structures and impair their function. Accurate head acceleration measurements are necessary to define the nature of the insult to the brain. A novel murine head tracking system was developed to improve the accuracy and efficiency of kinematic measurements obtained with high-speed videography. A three-dimensional (3D)-printed marker carrier was designed for rigid fixation to the upper jaw and incisors with an elastic strap around the snout. The system was evaluated by impacting cadaveric mice with the closed head impact model of engineered rotational acceleration (CHIMERA) system using an energy of 0.7\u2009J (5.29\u2009m\/s). We compared the performance of the head-marker system to the previously used skin-tracking method and documented significant improvements in measurement repeatability (aggregate coefficient of variation (CV) within raters from 15.8 to 1.5 and between raters from 15.5 to 1.5), agreement (aggregate percentage error from 24.9 to 8.7), and temporal response (aggregate temporal curve agreement from 0.668 to 0.941). Additionally, the new system allows for automated software tracking, which dramatically decreases the analysis time required (74% reduction). This novel head tracking system for mice offers an efficient, reliable, and real-time method to measure head kinematics during high-speed impacts using CHIMERA or other rodent or small mammal head impact models.<\/jats:p>","DOI":"10.1115\/1.4046202","type":"journal-article","created":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T05:49:53Z","timestamp":1580536193000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":2,"title":["An Automated Kinematic Measurement System for Sagittal Plane Murine Head Impacts"],"prefix":"10.1115","volume":"142","author":[{"given":"Kurt A.","family":"McInnes","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T 1Z4, Canada; International Collaboration on Repair Discoveries, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelalem A.","family":"Abebe","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T 1Z4, Canada; International Collaboration on Repair Discoveries, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Whyte","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T 1Z4, Canada; International Collaboration on Repair Discoveries, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Bashir","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Rm. G227 \u2013 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Barron","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Rm. G227 \u2013 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl L.","family":"Wellington","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Rm. G227 \u2013 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada; International Collaboration on Repair Discoveries, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Cripton","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T 1Z4, Canada; International Collaboration on Repair Discoveries, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada; Department of Orthopaedics, University of British Columbia, 11th Floor - 2775 Laurel Street Vancouver, BC V5Z 1M9, Canada; School of Biomedical Engineering, Unive"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"2020070605100446000_bib1","article-title":"Report to Congress on Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation","volume-title":"National Center for Injury Prevention and Control","author":"GA Centers for Disease Control and Prevention","year":"2015"},{"volume-title":"Incidence and Economic Burden of Injuries in the United States","year":"2006","key":"2020070605100446000_bib2"},{"issue":"4","key":"2020070605100446000_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1750-3639.1995.tb00618.x","article-title":"The Nature, Distribution and Causes of Traumatic Brain Injury","volume":"5","year":"1995","journal-title":"Brain Pathol. 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