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Thus far, femoral geometry has been given priority for the customization of total hip joint replacement (THR) implant design. This study, for the first time, demonstrates the key role of bone condition and subject-weight on the customization of stiffness and design of the femoral stem. In particular, internal hollowness was incorporated to reduce the implant stiffness and such designed structure has been customized based on subject parameters, including bone condition and bodyweight. The primary aim was to tailor these parameters to achieve close to natural strain distribution at periprosthetic bone and to reduce interfacial bone loss over time. The maintenance of interfacial bone density over time has been studied here through analysis of bone remodeling (BR). For normal bodyweight, the highest hollowness exhibited clinically relevant biomechanical response, for all bone conditions. However, for heavier subjects, consideration of bone quality was found to be essential as higher hollowness induced bone failure in weaker bones and implant failure in stronger bones. Moreover, for stronger bone, thinner medial wall was found to reduce bone resorption over time on the proximo-lateral zone of stress shielding, while lateral thinning was found advantageous for weaker bones. The findings of this study are likely to facilitate designing of femoral stems for achieving better physiological outcomes and enhancement of the quality of life of patients undergoing THR surgery.<\/jats:p>","DOI":"10.1115\/1.4046973","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T15:08:37Z","timestamp":1587568117000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":28,"title":["Biomechanical Analysis to Probe Role of Bone Condition and Subject Weight in Stiffness Customization of Femoral Stem for Improved Periprosthetic Biomechanical Response"],"prefix":"10.1115","volume":"142","author":[{"given":"Subhomoy","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Howrah, West Bengal 711103, India; Materials Research Centre, Indian Institute of Science, Bangalore, Karnataka 560012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandipan","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Howrah, West Bengal 711103, India; Department of Mechanical Engineering, SRM Institute of Science & Technology, Kattankulathur, Kancheepuram, Chennai, Tamil Nadu 603203, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Majumder","sequence":"first","affiliation":[{"name":"Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal 711103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"RoyChowdhury","sequence":"first","affiliation":[{"name":"Department of Aerospace Engineering and Applied Mechanics, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal 711103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"2020070808200153200_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jmbbm.2014.06.010","article-title":"Mechanical Properties of Human Bone\u2013Implant Interface Tissue in Aseptically Loose Hip Implants","volume":"38","year":"2014","journal-title":"J. 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