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Typically, ligaments are modeled using transversely isotropic, hyperelastic material models fitted to tension data along the predominant fiber direction (longitudinal) and, less commonly, to tension data orthogonal to the fiber direction (transverse). Currently, the shear and bulk responses of the anterior cruciate ligament (ACL) are not fitted to experimental data. In this study, a newly proposed material model was fitted to longitudinal tension, transverse tension, and shear experimental data. The matrix transverse tensile, shear, and bulk stiffnesses were then varied independently to determine the impact of each property on knee kinematics and tissue deformation in a whole-knee FE model. The range of values for each parameter was chosen based on published FE studies of the knee. For a knee at full extension under 134\u2009N anterior tibial force (ATF), increasing matrix transverse tensile stiffness, shear stiffness, or bulk stiffness decreased anterior tibial translation (ATT), ACL longitudinal strain, and ACL shear strain. For a knee under 134\u2009N ATF and 1600\u2009N compression, changing the ACL matrix mechanical properties caused variations in ATT and thus changed cartilage deformation contours by changing the point of contact between the femoral and the tibial cartilage. These findings indicate that material models for the ACL must describe matrix material properties to best predict the in vivo response to applied loads.<\/jats:p>","DOI":"10.1115\/1.4047658","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T03:10:33Z","timestamp":1593486633000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of Anterior Cruciate Ligament Matrix Mechanical Properties on Simulated Whole-Knee Biomechanics"],"prefix":"10.1115","volume":"142","author":[{"given":"Ryan","family":"Rosario","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C.","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen M.","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109; Department of Biomedical Engineering, Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhima M.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"issue":"6","key":"2020090904472099000_bib1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0363546516629944","article-title":"Incidence of Anterior Cruciate Ligament Tears and Reconstruction: A 21-Year Population-Based Study","volume":"44","year":"2016","journal-title":"Am. 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