{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:57:08Z","timestamp":1768712228609,"version":"3.49.0"},"reference-count":43,"publisher":"ASME International","issue":"1","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although alterations in bone mineral density (BMD) at the proximal tibia have been suggested to play a role in various musculoskeletal conditions, their pathophysiological implications and their value as markers for diagnosis remain unclear. Improving our understanding of proximal tibial BMD requires novel tools for three-dimensional (3D) analysis of BMD distribution. Three-dimensional imaging is possible with computed tomography (CT), but computational anatomy algorithms are missing to standardize the quantification of 3D proximal tibial BMD, preventing distribution analyses. The objectives of this study were to develop and assess a registration method, suitable with routine knee CT scans, to allow the standardized quantification of 3D BMD distribution in the proximal tibia. Second, as an example of application, the study aimed to characterize the distribution of BMD below the tibial cartilages in healthy knees. A method was proposed to register both the surface (vertices) and the content (voxels) of proximal tibias. The method combines rigid transformations to account for differences in bone size and position in the scanner's field of view and to address inconsistencies in the portion of the tibial shaft included in routine CT scan, with a nonrigid transformation locally matching the proximal tibias. The method proved to be highly reproducible and provided a comprehensive description of the relationship between bone depth and BMD. Specifically it reported significantly higher BMD in the first 6\u2009mm of bone than deeper in the proximal tibia. In conclusion, the proposed method offers promising possibilities to analyze BMD and other properties of the tibia in 3D.<\/jats:p>","DOI":"10.1115\/1.4048335","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T03:27:26Z","timestamp":1599103646000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":4,"title":["A Registration Method for Three-Dimensional Analysis of Bone Mineral Density in the Proximal Tibia"],"prefix":"10.1115","volume":"143","author":[{"given":"Hugo","family":"Babel","sequence":"first","affiliation":[{"name":"Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"W\u00e4geli","sequence":"additional","affiliation":[{"name":"Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berke","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Thiran","sequence":"additional","affiliation":[{"name":"Signal Processing Laboratory, Ecole Polytechnique F\u00e9d\u00e9rale Lausanne (EPFL), Lausanne CH-1015, Switzerland;"},{"name":"Service of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Omoumi","sequence":"additional","affiliation":[{"name":"Service of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte M.","family":"Jolles","sequence":"additional","affiliation":[{"name":"Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"},{"name":"Institute of Microengineering, Ecole Polytechnique F\u00e9d\u00e9rale Lausanne (EPFL), Lausanne CH-1015, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Favre","sequence":"additional","affiliation":[{"name":"Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne CH-1011, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"issue":"2","key":"2020092905334945200_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.joca.2007.07.007","article-title":"Meniscal Damage Associated With Increased Local Subchondral Bone Mineral Density: A Framingham Study","volume":"16","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"2020092905334945200_bib2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.knee.2018.06.005","article-title":"Two-Year Follow-Up of Bone Mineral Density Changes in the Knee After Meniscal Allograft Transplantation: Results of an Explorative Study","volume":"25","year":"2018","journal-title":"Knee"},{"issue":"1","key":"2020092905334945200_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.joca.2013.11.005","article-title":"Bone Mineral Density Changes in the Knee Following Anterior Cruciate Ligament Rupture","volume":"22","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"2020092905334945200_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.knee.2008.05.005","article-title":"Regional Bone Density Changes in Anterior Cruciate Ligament Deficient Knees: A DEXA Study","volume":"15","year":"2008","journal-title":"Knee"},{"issue":"3","key":"2020092905334945200_bib5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00198-013-2557-5","article-title":"Bone Mineral and Stiffness Loss at the Distal Femur and Proximal Tibia in Acute Spinal Cord Injury","volume":"25","year":"2014","journal-title":"Osteoporosis Int."},{"issue":"3","key":"2020092905334945200_bib6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/jor.1100100309","article-title":"Osteoporosis After Spinal Cord Injury","volume":"10","year":"1992","journal-title":"J. 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