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DT is being widely used nowadays, however, as there are several uses in the existing literature; the understanding of the concept and its functioning can be diffuse. The main goal of this paper is to provide a review of the existing literature to clarify the concept, operation, and main characteristics of DT, to introduce the most current operating, communication, and usage trends related to this technology, and to present the performance of the synergy between DT and multi-agent system (MAS) technologies through a computer science approach.<\/jats:p>","DOI":"10.1115\/1.4050244","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T16:04:36Z","timestamp":1614009876000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":182,"title":["Digital Twins: Review and Challenges"],"prefix":"10.1115","volume":"21","author":[{"given":"Maria G.","family":"Juarez","sequence":"first","affiliation":[{"name":"Information Systems and Computing Department (DSIC), Valencian Research Institute for, Artificial Intelligence, Universitat Polit\u00e9cnica de Val\u00e9ncia, Valencia 46022, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente J.","family":"Botti","sequence":"additional","affiliation":[{"name":"Information Systems and Computing Department (DSIC), Valencian Research Institute for, Artificial Intelligence, Universitat Polit\u00e9cnica de Valencia, Valencia 46022, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S.","family":"Giret","sequence":"additional","affiliation":[{"name":"Information Systems and Computing Department (DSIC), Valencian Research Institute for, Artificial Intelligence, Universitat Polit\u00e9cnica de Val\u00e9ncia, Valencia 46022, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"2021051217444577500_CIT0001","article-title":"Recommendations for Implementing the Strategic Initiative INDUSTRIE 4.0: Securing the Future of German Manufacturing Industry","author":"Kagermann","year":"2013"},{"key":"2021051217444577500_CIT0002","first-page":"171","article-title":"A Six-Layer Architecture for Digital Twins With Aggregation","author":"Redelinghuys","year":"2019"},{"issue":"11","key":"2021051217444577500_CIT0003","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.ifacol.2018.08.474","article-title":"Digital Twin in Manufacturing: A Categorical Literature Review and Classification","volume":"51","author":"Kritzinger","year":"2018","journal-title":"IFAC-PapersOnLine"},{"key":"2021051217444577500_CIT0004","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mfglet.2014.12.001","article-title":"A Cyber-Physical Systems Architecture for Industry 4.0-Based Manufacturing Systems","volume":"3","author":"Lee","year":"2015","journal-title":"Manuf. 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