{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:22:51Z","timestamp":1790410971426,"version":"4.1.0"},"reference-count":68,"publisher":"ASME International","issue":"8","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Osteogenesis imperfecta (OI), also known as \u201cbrittle bone disease,\u201d is a genetic bone disorder. OI bones experience frequent fractures. Surgical procedures are usually followed by clinicians in the management of OI. It has been observed physical activity is equally beneficial in reducing OI bone fractures in both children and adults as mechanical stimulation improves bone mass and strength. Loading-induced mechanical strain and interstitial fluid flow stimulate bone remodeling activities. Several studies have characterized strain environment in OI bones, whereas very few studies attempted to characterize the interstitial fluid flow. OI significantly affects bone micro-architecture. Thus, this study anticipates that canalicular fluid flow reduces in OI bone in comparison to the healthy bone in response to physiological loading due to altered poromechanical properties. This work attempts to understand the canalicular fluid distribution in single osteon models of OI and healthy bone. A poromechanical model of osteon is developed to compute pore-pressure and interstitial fluid flow as a function of gait loading pattern reported for OI and healthy subjects. Fluid distribution patterns are compared at different time-points of the stance phase of the gait cycle. It is observed that fluid flow significantly reduces in OI bone. Additionally, flow is more static than dynamic in OI osteon in comparison to healthy subjects. This work attempts to identify the plausible explanation behind the diminished mechanotransduction capability of OI bone. This work may further be extended for designing better biomechanical therapies to enhance the fluid flow in order to improve osteogenic activities in OI bone.<\/jats:p>","DOI":"10.1115\/1.4050818","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T09:46:16Z","timestamp":1617961576000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":8,"title":["Physiological Loading-Induced Interstitial Fluid Dynamics in Osteon of Osteogenesis Imperfecta Bone"],"prefix":"10.1115","volume":"143","author":[{"given":"Nikhil Vivek","family":"Shrivas","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India; Department of Mechatronics Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek Kumar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh 211004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan 303007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Mathematics, National Institute of Technology Uttarakhand, Srinagar, Uttarakhand 246174, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subham","family":"Badhyal","sequence":"additional","affiliation":[{"name":"Sports Authority of India, Jawahar Lal Nehru Stadium, Lodhi Road, New Delhi 110003, India; MYAS-GNDU Department of Sports Sciences and Medicine, Guru Nanak Dev University, Amritsar, Punjab 143005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"issue":"6","key":"2021050607475681500_bib1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/jmg.30.6.492","article-title":"Osteogenesis Imperfecta Type III: Mutations in the Type I Collagen Structural Genes, COL1A1 and COL1A2, Are Not Necessarily Responsible","volume":"30","year":"1993","journal-title":"J. Med. Genet."},{"issue":"9418","key":"2021050607475681500_bib2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis Imperfecta","volume":"363","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"2021050607475681500_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.me.43.020192.001413","article-title":"Osteogenesis Imperfecta","volume":"43","year":"1992","journal-title":"Annu. Rev. Med."},{"key":"2021050607475681500_bib4","first-page":"367","article-title":"Current and Emerging Treatments for the Management of Osteogenesis Imperfecta","volume":"6","year":"2010","journal-title":"Ther. Clin. Risk Manage."},{"issue":"4\u20135","key":"2021050607475681500_bib5","first-page":"240","article-title":"Complications After Treatment of Patients With Osteogenesis Imperfecta With a Bailey-Dubow Rod","volume":"117","year":"1998","journal-title":"Arch. Orthop. Trauma Surg."},{"issue":"4","key":"2021050607475681500_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5435\/00124635-199807000-00004","article-title":"Osteogenesis Imperfecta","volume":"6","year":"1998","journal-title":"JAAOS J. Am. Acad. Orthop. Surg."},{"issue":"2","key":"2021050607475681500_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"Markers of Bone Turnover for the Prediction of Fracture Risk and Monitoring of Osteoporosis Treatment: A Need for International Reference Standards","volume":"22","year":"2011","journal-title":"Osteoporosis Int."},{"issue":"Suppl. 2","key":"2021050607475681500_bib8","first-page":"S150","article-title":"Bisphosphonates: Mode of Action and Pharmacology","volume":"119","year":"2007","journal-title":"Pediatrics"},{"issue":"7","key":"2021050607475681500_bib9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1359\/JBMR.050213","article-title":"Effects of Intravenous Pamidronate Treatment in Infants With Osteogenesis Imperfecta: Clinical and Histomorphometric Outcome","volume":"20","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"2021050607475681500_bib10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0025-6196(11)60752-0","article-title":"Adverse Effects of Bisphosphonates: Implications for Osteoporosis Management","volume":"84","year":"2009","journal-title":"Mayo Clin. Proc."},{"issue":"8","key":"2021050607475681500_bib11","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jbmr.2222","article-title":"Age-Related Impairment of Bones' Adaptive Response to Loading in Mice Is Associated With Sex-Related Deficiencies in Osteoblasts but No Change in Osteocytes","volume":"29","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"2021050607475681500_bib12","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0021-9290(03)00127-1","article-title":"Fluid Pressure Gradients, Arising From Oscillations in Intramedullary Pressure, Is Correlated With the Formation of Bone and Inhibition of Intracortical Porosity","volume":"36","year":"2003","journal-title":"J. Biomech."},{"issue":"2","key":"2021050607475681500_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10237-016-0824-z","article-title":"Computer Modelling of Bone's Adaptation: The Role of Normal Strain, Shear Strain and Fluid Flow","volume":"16","year":"2017","journal-title":"Biomech. Model. Mechanobiol."},{"key":"2021050607475681500_bib14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jtbi.2018.03.009","article-title":"In Silico Modeling of Bone Adaptation to Rest-Inserted Loading: Strain Energy Density Versus Fluid Flow as Stimulus","volume":"446","year":"2018","journal-title":"J. Theor. Biol."},{"key":"2021050607475681500_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jtbi.2019.03.023","article-title":"Canalicular Fluid Flow Induced by Loading Waveforms: A Comparative Analysis","volume":"471","year":"2019","journal-title":"J. Theor. Biol."},{"issue":"9","key":"2021050607475681500_bib16","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.medengphy.2009.06.010","article-title":"A Fracture Risk Assessment Model of the Femur in Children With Osteogenesis Imperfecta (OI) During Gait","volume":"31","year":"2009","journal-title":"Med. Eng. Phys."},{"key":"2021050607475681500_bib17","first-page":"4884","article-title":"Biomechanics of Femoral Deformity in Osteogenesis Imperfecta (OI): A Quantitative Approach to Rehabilitation","volume-title":"26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","year":"2004"},{"issue":"4","key":"2021050607475681500_bib18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11517-016-1526-5","article-title":"Geometry Reconstruction Method for Patient-Specific Finite Element Models for the Assessment of Tibia Fracture Risk in Osteogenesis Imperfecta","volume":"55","year":"2017","journal-title":"Med. Biol. Eng. Comput."},{"issue":"10","key":"2021050607475681500_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1138\/20060233","article-title":"Mechanosensation and Transduction in Osteocytes","volume":"3","year":"2006","journal-title":"BoneKEy Osteovision"},{"issue":"6","key":"2021050607475681500_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00198-009-0858-5","article-title":"The Role of Osteocytes in Bone Mechanotransduction","volume":"20","year":"2009","journal-title":"Osteoporos Int."},{"issue":"5","key":"2021050607475681500_bib21","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s10237-020-01314-7","article-title":"Signalling Molecule Transport Analysis in Lacunar\u2013Canalicular System","volume":"19","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"2021050607475681500_bib22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bone.2013.12.020","article-title":"Altered Lacunar and Vascular Porosity in Osteogenesis Imperfecta Mouse Bone as Revealed by Synchrotron Tomography Contributes to Bone Fragility","volume":"61","year":"2014","journal-title":"Bone"},{"issue":"4","key":"2021050607475681500_bib23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4103\/ortho.IJOrtho_291_18","article-title":"Kinetic and Kinematic Analysis of Gait in Type IV Osteogenesis Imperfecta Patients: A Comparative Study","volume":"53","year":"2019","journal-title":"Indian J. Orthop."},{"key":"2021050607475681500_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.euromechsol.2012.12.005","article-title":"A Hollow Osteon Model for Examining Its Poroelastic Behaviors: Mathematically Modeling an Osteon With Different Boundary Cases","volume":"40","year":"2013","journal-title":"Eur. J. Mech.-A\/Solids"},{"issue":"S2","key":"2021050607475681500_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12938-016-0267-x","article-title":"Mathematically Modeling Fluid Flow and Fluid Shear Stress in the Canaliculi of a Loaded Osteon","volume":"15","year":"2016","journal-title":"Biomed. Eng. Online"},{"issue":"3","key":"2021050607475681500_bib26","first-page":"607","article-title":"Unique Bone Histology in Partial Large Bone Shafts From Upper Triassic of Aust Cliff, England: An Early Independent Experiment in Gigantism","volume":"59","year":"2012","journal-title":"Acta Palaeontol. Pol."},{"issue":"2","key":"2021050607475681500_bib27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ajpa.1330840207","article-title":"Histologic Estimation of Age at Death Using the Anterior Cortex of the Femur","volume":"84","year":"1991","journal-title":"Am. J. Phys. Anthropol."},{"issue":"5","key":"2021050607475681500_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00223-013-9771-1","article-title":"The Long Bone Deformity of Osteogenesis Imperfecta III: Analysis of Structural Changes Carried Out With Scanning Electron Microscopic Morphometry","volume":"93","year":"2013","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"2021050607475681500_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.mechrescom.2010.01.008","article-title":"Poroviscoelasticity of Transversely Isotropic Cylinders Under Laboratory Loading Conditions","volume":"37","year":"2010","journal-title":"Mech. Res. Commun."},{"issue":"2","key":"2021050607475681500_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1350-4533(00)00021-7","article-title":"Canalicular Fluid Flow Induced by Bending of a Long Bone","volume":"22","year":"2000","journal-title":"Med. Eng. Phys."},{"issue":"33","key":"2021050607475681500_bib31","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1073\/pnas.0505193102","article-title":"In Situ Measurement of Solute Transport in the Bone Lacunar-Canalicular System","volume":"102","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"2021050607475681500_bib32","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00774-007-0764-x","article-title":"A Histological Assessment on the Distribution of the Osteocytic Lacunar Canalicular System Using Silver Staining","volume":"25","year":"2007","journal-title":"J. Bone Miner. Metab."},{"issue":"5","key":"2021050607475681500_bib33","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.crme.2009.06.033","article-title":"Numerical Study of Deformation-Induced Fluid Flows in Periodic Osteonal Matrix Under Harmonic Axial Loading","volume":"337","year":"2009","journal-title":"C. R. Mec."},{"key":"2021050607475681500_bib34","first-page":"177","volume-title":"Material and Structural Aspects of Bone in Osteogenesis Imperfecta","year":"2016"},{"issue":"3","key":"2021050607475681500_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11242-004-6298-y","article-title":"Drained and Undrained Poroelastic Properties of Healthy and Pathological Bone: A Poro-Micromechanical Investigation","volume":"58","year":"2005","journal-title":"Transp. Porous Media"},{"issue":"6","key":"2021050607475681500_bib36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0021-9290(02)00021-0","article-title":"Estimation of the Poroelastic Parameters of Cortical Bone","volume":"35","year":"2002","journal-title":"J. Biomech."},{"key":"2021050607475681500_bib37","doi-asserted-by":"crossref","first-page":"86721\u2009L","DOI":"10.1117\/12.2007209","article-title":"3D Micron-Scale Imaging of the Cortical Bone Canal Network in Human Osteogenesis Imperfecta (OI)","volume":"8672","year":"2013","journal-title":"Proc. SPIE"},{"issue":"1","key":"2021050607475681500_bib38","doi-asserted-by":"crossref","first-page":"011002","DOI":"10.1115\/1.3172146","article-title":"Poromechanics Solutions to Plane Strain and Axisymmetric Mandel-Type Problems in Dual-Porosity and Dual-Permeability Medium","volume":"77","year":"2010","journal-title":"ASME J. Appl. Mech."},{"issue":"2","key":"2021050607475681500_bib39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2118\/105383-PA","article-title":"Analyses of Wellbore Instability in Drilling Through Chemically Active Fractured-Rock Formations","volume":"14","year":"2009","journal-title":"SPE J."},{"issue":"4","key":"2021050607475681500_bib40","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.medengphy.2010.02.001","article-title":"Poroelastic Behaviour of Cortical Bone Under Harmonic Axial Loading: A Finite Element Study at the Osteonal Scale","volume":"32","year":"2010","journal-title":"Med. Eng. Phys."},{"key":"2021050607475681500_bib41","article-title":"Characterization of Bone Material Properties and Microstructure in Osteogenesis Imperfecta\/Brittle Bone Disease","volume-title":"413","year":"2014"},{"issue":"3","key":"2021050607475681500_bib42","first-page":"256","article-title":"Mechanosensation and Fluid Transport in Living Bone","volume":"2","year":"2002","journal-title":"J. Musculoskeletal Neuronal Interact."},{"issue":"1","key":"2021050607475681500_bib43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12938-018-0528-y","article-title":"A Multi-Layered Poroelastic Slab Model Under Cyclic Loading for a Single Osteon","volume":"17","year":"2018","journal-title":"Biomed. Eng. Online"},{"issue":"1","key":"2021050607475681500_bib44","first-page":"1","article-title":"Study on the Biomechanical Responses of the Loaded Bone in Macroscale and Mesoscale by Multiscale Poroelastic FE Analysis","volume":"18","year":"2019","journal-title":"Biomed. Eng. Online"},{"issue":"1","key":"2021050607475681500_bib45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1115\/1.1535191","article-title":"Micromechanically Based Poroelastic Modeling of Fluid Flow in Haversian Bone","volume":"125","year":"2003","journal-title":"ASME J. Biomech. Eng."},{"issue":"9","key":"2021050607475681500_bib46","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.1021\/nn401360u","article-title":"Osteocytic Canalicular Networks: Morphological Implications for Altered Mechanosensitivity","volume":"7","year":"2013","journal-title":"ACS Nano"},{"issue":"3","key":"2021050607475681500_bib47","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10237-019-01250-1","article-title":"Network Architecture Strongly Influences the Fluid Flow Pattern Through the Lacunocanalicular Network in Human Osteons","volume":"19","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"1","key":"2021050607475681500_bib48","first-page":"25","article-title":"Mathematical Modeling of Human Secondary Osteons","volume":"26","year":"2004","journal-title":"Scanning J. Scanning Microsc."},{"issue":"3","key":"2021050607475681500_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2818.2010.03431.x","article-title":"AFM Analysis of the Lacunar-Canalicular Network in Demineralized Compact Bone","volume":"241","year":"2011","journal-title":"J. Microsc."},{"issue":"7","key":"2021050607475681500_bib50","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s10439-009-9706-1","article-title":"Poroelastic Evaluation of Fluid Movement Through the Lacunocanalicular System","volume":"37","year":"2009","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"2021050607475681500_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10439-005-8959-6","article-title":"Modeling Deformation-Induced Fluid Flow in Cortical Bone's Canalicular\u2013Lacunar System","volume":"33","year":"2005","journal-title":"Ann. Biomed. Eng."},{"issue":"2","key":"2021050607475681500_bib52","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jbiomech.2012.10.025","article-title":"Advances in Assessment of Bone Porosity, Permeability and Interstitial Fluid Flow","volume":"46","year":"2013","journal-title":"J. Biomech."},{"issue":"9001","key":"2021050607475681500_bib53","first-page":"S101","article-title":"Mechanotransduction in Bone\u2014Role of the Lacunocanalicular Network","volume":"13","year":"1999","journal-title":"FASEB J."},{"issue":"5","key":"2021050607475681500_bib54","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11914-017-0402-z","article-title":"Aging, Osteocytes, and Mechanotransduction","volume":"15","year":"2017","journal-title":"Curr. Osteoporosis Rep."},{"issue":"9","key":"2021050607475681500_bib55","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/jbmr.3180","article-title":"Hypermineralization and High Osteocyte Lacunar Density in Osteogenesis Imperfecta Type V Bone Indicate Exuberant Primary Bone Formation","volume":"32","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"2021050607475681500_bib56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jmbbm.2014.12.020","article-title":"Microstructure and Compressive Mechanical Properties of Cortical Bone in Children With Osteogenesis Imperfecta Treated With Bisphosphonates Compared With Healthy Children","volume":"46","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"2021050607475681500_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bone.2014.09.003","article-title":"Increased Intra-Cortical Porosity Reduces Bone Stiffness and Strength in Pediatric Patients With Osteogenesis Imperfecta","volume":"69","year":"2014","journal-title":"Bone"},{"issue":"8","key":"2021050607475681500_bib58","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/jbmr.1927","article-title":"Architecture of the Osteocyte Network Correlates With Bone Material Quality","volume":"28","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"2021050607475681500_bib59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10237-013-0487-y","article-title":"Fluid Flow in the Osteocyte Mechanical Environment: A Fluid\u2013Structure Interaction Approach","volume":"13","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"key":"2021050607475681500_bib60","doi-asserted-by":"crossref","first-page":"e04645","DOI":"10.7554\/eLife.04645","article-title":"Vascular Remodeling Is Governed by a VEGFR3-Dependent Fluid Shear Stress Set Point","volume":"4","year":"2015","journal-title":"eLife"},{"issue":"12","key":"2021050607475681500_bib61","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s10439-008-9566-0","article-title":"Modeling Fluorescence Recovery After Photobleaching in Loaded Bone: Potential Applications in Measuring Fluid and Solute Transport in the Osteocytic Lacunar-Canalicular System","volume":"36","year":"2008","journal-title":"Ann. Biomed. Eng."},{"issue":"S1","key":"2021050607475681500_bib62","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1007\/BF02406134","article-title":"Functional Strain as a Determinant for Bone Remodeling","volume":"36","year":"1984","journal-title":"Calcif. Tissue Int."},{"key":"2021050607475681500_bib63","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bonr.2017.03.001","article-title":"Spatial Heterogeneity in the Canalicular Density of the Osteocyte Network in Human Osteons","volume":"6","year":"2017","journal-title":"Bone Rep."},{"key":"2021050607475681500_bib64","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bone.2019.03.018","article-title":"The Contribution of the Pericanalicular Matrix to Mineral Content in Human Osteonal Bone","volume":"123","year":"2019","journal-title":"Bone"},{"issue":"4","key":"2021050607475681500_bib65","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/jbmr.3354","article-title":"Understanding Age-Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor","volume":"33","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"2\u20133","key":"2021050607475681500_bib66","first-page":"191","article-title":"Histological Estimation of Age at Death Using Microradiographs of Humeral Compact Bone","volume":"64","year":"1994","journal-title":"Forensic Sci. Int."},{"issue":"6","key":"2021050607475681500_bib67","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.mechrescom.2004.10.003","article-title":"Transverse Isotropic Poroelastic Osteon Model Under Cyclic Loading","volume":"32","year":"2005","journal-title":"Mech. Res. Commun."},{"issue":"4","key":"2021050607475681500_bib68","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10483-013-1680-x","article-title":"Mathematical Osteon Model for Examining Poroelastic Behaviors","volume":"34","year":"2013","journal-title":"Appl. Math. Mech. Engl. Ed."}],"container-title":["Journal of Biomechanical Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/143\/8\/081011\/6692244\/bio_143_08_081011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/143\/8\/081011\/6692244\/bio_143_08_081011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T01:24:34Z","timestamp":1620350674000},"score":1,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article\/143\/8\/081011\/1106937\/Physiological-Loading-Induced-Interstitial-Fluid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,6]]},"references-count":68,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1115\/1.4050818","relation":{},"ISSN":["0148-0731","1528-8951"],"issn-type":[{"value":"0148-0731","type":"print"},{"value":"1528-8951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,6]]},"article-number":"081011"}}