{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:55:39Z","timestamp":1784573739778,"version":"3.55.0"},"reference-count":97,"publisher":"ASME International","issue":"12","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"funder":[{"DOI":"10.13039\/100000147","name":"Division of Civil, Mechanical and Manufacturing Innovation","doi-asserted-by":"publisher","award":["1751050"],"award-info":[{"award-number":["1751050"]}],"id":[{"id":"10.13039\/100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The vagina is a viscoelastic fibromuscular organ that provides support to the pelvic organs. The viscoelastic properties of the vagina are understudied but may be critical for pelvic stability. Most studies evaluate vaginal viscoelasticity under a single uniaxial load; however, the vagina is subjected to dynamic multiaxial loading in the body. It is unknown how varied multiaxial loading conditions affect vaginal viscoelastic behavior and which microstructural processes dictate the viscoelastic response. Therefore, the objective was to develop methods using extension-inflation protocols to quantify vaginal viscoelastic creep under various circumferential and axial loads. Then, the protocol was applied to quantify vaginal creep and collagen microstructure in the fibulin-5 wildtype and haploinsufficient vaginas. To evaluate pressure-dependent creep, the fibulin-5 wildtype and haploinsufficient vaginas (n\u2009=\u20097\/genotype) were subjected to various constant pressures at the physiologic length for 100\u2009s. For axial length-dependent creep, the vaginas (n\u2009=\u20097\/genotype) were extended to various fixed axial lengths then subjected to the mean in vivo pressure for 100\u2009s. Second-harmonic generation imaging was performed to quantify collagen fiber organization and undulation (n\u2009=\u20093\/genotype). Increased pressure significantly increased creep strain in the wildtype, but not the haploinsufficient vagina. The axial length did not significantly affect the creep rate or strain in both genotypes. Collagen undulation varied through the depth of the subepithelium but not between genotypes. These findings suggest that the creep response to loading may vary with biological processes and pathologies, therefore, evaluating vaginal creep under various circumferential loads may be important to understand vaginal function.<\/jats:p>","DOI":"10.1115\/1.4052365","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T07:46:36Z","timestamp":1631087196000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of Murine Vaginal Creep Response to Altered Mechanical Loads"],"prefix":"10.1115","volume":"143","author":[{"given":"Gabrielle L.","family":"Clark-Patterson","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Tulane University , 6823\u2009St Charles Ave., New Orleans, LA 70118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Mechanics, Virginia Tech , 330 A Kelly Hall, 325 Stanger Street, Blacksburg, VA 24061"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurephile","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Female Pelvic Medicine & Reconstructive Surgery, University of Queensland Ochsner Clinical School , 1514 Jefferson Highway, New Orleans, LA 70121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leise R.","family":"Knoepp","sequence":"additional","affiliation":[{"name":"Department of Female Pelvic Medicine & Reconstructive Surgery, University of Queensland Ochsner Clinical School , 1514 Jefferson Highway, New Orleans, LA 70121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"De Vita","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Mechanics, Virginia Tech , 330 A Kelly Hall, 325 Stanger Street, Blacksburg, VA 24061"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tulane University , 6823\u2009St Charles Ave., New Orleans, LA 70118"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"issue":"4","key":"2022101100100956500_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF01894267","article-title":"Viscoelastic Properties and Muscular Function of the Human Anterior Vaginal Wall","volume":"6","year":"1995","journal-title":"Int. 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