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The proper regulation of extracellular matrix (ECM) turnover leads to remodeling throughout gestation, transforming the tissue from a stiff material to a compliant, extensible, viscoelastic tissue prepared for delivery. Small leucine-rich proteoglycans (SLRPs) regulate structural fiber assembly in the cervical ECM and overall tissue material properties. To quantify the SLRPs' mechanical role in the cervix, whole cervix specimens from nonpregnant and late pregnant knockout mice of SLRPs, decorin and biglycan, were subjected to cyclic load-unload, ramp-hold, and load-to-failure mechanical tests. Further, a fiber composite material model, accounting for collagen fiber bundle waviness, was developed to describe the cervix's three-dimensional large deformation equilibrium behavior. In nonpregnant tissue, SLRP knockout cervices have the same equilibrium material properties as wild-type tissue. In contrast, the load-to-failure and ramp-hold tests reveal SLRPs impact rupture and time-dependent relaxation behavior. Loss of decorin in nonpregnant (NP) cervices results in inferior rupture properties. After extensive remodeling, cervical strength is similar between all genotypes, but the SLRP-deficient tissue has a diminished ability to dissipate stress during a ramp-hold. In mice with a combined loss of decorin and biglycan, the pregnant cervix loses its extensibility, compliance, and viscoelasticity. These results suggest that decorin and biglycan are necessary for crucial extensibility and viscoelastic material properties of a healthy, remodeled pregnant cervix.<\/jats:p>","DOI":"10.1115\/1.4054199","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T19:27:02Z","timestamp":1648582022000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":11,"title":["Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy"],"prefix":"10.1115","volume":"144","author":[{"given":"Nicole","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Columbia University, New York , NY 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Columbia University, New York , NY 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Colon Caraballo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cecil H. and Ida Green Center for Reproductive Biological Science, The University of Texas, Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmugasundaram","family":"Nallasamy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cecil H. and Ida Green Center for Reproductive Biological Science, The University of Texas, Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Mahendroo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cecil H. and Ida Green Center for Reproductive Biological Science, The University of Texas, Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato V.","family":"Iozzo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anatomy and Cell Biology and the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University , Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Columbia University, New York , NY 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"2023041500103384400_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.12688\/gatesopenres.13098.1","article-title":"Building a Global Policy Agenda to Prioritize Preterm Birth: A Qualitative Analysis on Factors Shaping Global Health Policymaking","volume":"4","year":"2020","journal-title":"Gates Open Res."},{"key":"2023041500103384400_","author":"Preterm Birth,\u201d World Health Organization, Geneva, Switzerland, accessed Sept. 2021,"},{"issue":"7","key":"2023041500103384400_","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.semperi.2017.07.014","article-title":"Seminars in Perinatology the Pathophysiology of Human Premature Cervical Remodeling Resulting in Spontaneous Preterm Birth: Where Are we Now?","volume":"41","year":"2017","journal-title":"Semin. 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