{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:45:36Z","timestamp":1792507536818,"version":"4.5.0"},"reference-count":60,"publisher":"ASME International","issue":"10","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients with acquired and congenital cardiac valve disease. Image-derived computational modeling of atrioventricular valves has advanced substantially over the last decade and holds particular promise to inform valve repair in small and heterogeneous populations, which are less likely to be optimized through empiric clinical application. While an abundance of computational biomechanics studies has investigated mitral and tricuspid valve disease in adults, few studies have investigated its application to vulnerable pediatric and congenital heart populations. Further, to date, investigators have primarily relied upon a series of commercial applications that are neither designed for image-derived modeling of cardiac valves nor freely available to facilitate transparent and reproducible valve science. To address this deficiency, we aimed to build an open-source computational framework for the image-derived biomechanical analysis of atrioventricular valves. In the present work, we integrated an open-source valve modeling platform, SlicerHeart, and an open-source biomechanics finite element modeling software, FEBio, to facilitate image-derived atrioventricular valve model creation and finite element analysis. We present a detailed verification and sensitivity analysis to demonstrate the fidelity of this modeling in application to three-dimensional echocardiography-derived pediatric mitral and tricuspid valve models. Our analyses achieved an excellent agreement with those reported in the literature. As such, this evolving computational framework offers a promising initial foundation for future development and investigation of valve mechanics, in particular collaborative efforts targeting the development of improved repairs for children with congenital heart disease.<\/jats:p>","DOI":"10.1115\/1.4054485","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T08:25:21Z","timestamp":1651739121000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":23,"title":["A Computational Framework for Atrioventricular Valve Modeling Using Open-Source Software"],"prefix":"10.1115","volume":"144","author":[{"given":"Wensi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ching","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A.","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Scientific Computing and Imaging Institute, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Lasso","sequence":"additional","affiliation":[{"name":"Laboratory for Percutaneous Surgery, Queen's University , Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Sabin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Scientific Computing and Imaging Institute, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Jolley","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Pediatric Cardiology, Children's Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"issue":"6","key":"2022052709532168900_bib1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.CIR.0000025426.39426.83","article-title":"Effect of Annular Shape on Leaflet Curvature in Reducing Mitral Leaflet Stress","volume":"106","year":"2002","journal-title":"Circulation"},{"issue":"12","key":"2022052709532168900_bib2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/CIRCULATIONAHA.109.901181","article-title":"Mitral Annular Dynamics in Myxomatous Valve Disease","volume":"121","year":"2010","journal-title":"Circulation"},{"issue":"11_suppl_1","key":"2022052709532168900_bib3","first-page":"S183","article-title":"Three-Dimensional Echocardiographic Analysis of Mitral Annular Dynamics","volume":"126","year":"2012","journal-title":"Circulation"},{"key":"2022052709532168900_bib4","first-page":"416","article-title":"A High-Fidelity and Micro-Anatomically Accurate 3D Finite Element Model for Simulations of Functional Mitral Valve","volume":"7945","year":"2013","journal-title":"LNCS"},{"issue":"8","key":"2022052709532168900_bib5","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1007\/s10439-018-2024-8","article-title":"Finite Element Analysis of Tricuspid Valve Deformation From Multi-Slice Computed Tomography Images","volume":"46","year":"2018","journal-title":"Ann. 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