{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:55:33Z","timestamp":1753880133644,"version":"3.41.2"},"reference-count":42,"publisher":"ASME International","issue":"5","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["Grant No. 2022A0122B06721"],"award-info":[{"award-number":["Grant No. 2022A0122B06721"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T000414\/1"],"award-info":[{"award-number":["EP\/T000414\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ureteroscopy is a commonly performed medical procedure to treat stones in the kidney and ureter using a ureteroscope. Throughout the procedure, saline is irrigated through the scope to aid visibility and wash-out debris from stone fragmentation. The key challenge that this research addresses is to build a fundamental understanding of the interaction between the kidney stones\/stone fragments and the flow dynamics in the renal pelvis flow. We examine the time-dependent flow dynamics inside an idealized renal pelvis in the context of a surgical procedure for kidney stone removal. Here, we examine the time-dependent evolution of these vortical flow structures in three dimensions, and incorporate the presence of rigid kidney stones. We perform direct numerical simulations, solving the transient Navier\u2013Stokes equations in a spherical domain. Our numerical predictions for the flow dynamics in the absence of stones are validated with available experimental and numerical data, and the governing parameters and flow regimes are chosen carefully in order to satisfy several clinical constraints. The results shed light on the crucial role of flow circulation in the renal cavity and its effect on the trajectories of rigid stones. We demonstrate that stones can either be washed out of the cavity along with the fluid, or be trapped in the cavity via their interaction with vortical flow structures. Additionally, we study the effect of multiple stones in the flow field within the cavity in terms of the kinetic energy, entrapped fluid volume, and the clearance rate of a passive tracer modeled via an advection\u2013diffusion equation. We demonstrate that the flow in the presence of stones features a higher vorticity production within the cavity compared with the stone-free cases.<\/jats:p>","DOI":"10.1115\/1.4056461","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T09:31:13Z","timestamp":1670923873000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":2,"title":["Role of Kidney Stones in Renal Pelvis Flow"],"prefix":"10.1115","volume":"145","author":[{"given":"C. R.","family":"Constante-Amores","sequence":"first","affiliation":[{"name":"Mathematical Institute, University of Oxford , Oxford OX2 6GG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kahouadji","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Imperial College London , London SW7 2AZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Williams","sequence":"additional","affiliation":[{"name":"Urology & Pelvic Health Division, Boston Scientific Corporation , Marlborough, MA 01752"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. W.","family":"Turney","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences, University of Oxford John Radcliffe Hospital , Oxford OX2 6GG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Mechanical and System Design Engineering, Hongik University , Seoul 04066, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chergui","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay, LISN, CNRS , Orsay 91405, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Juric","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay, LISN, CNRS , Orsay 91405, France ; , Cambridge CB3 0WA, UK"},{"name":"Department of Applied Mathematics and Theoretical Physics, University of Cambridge , Orsay 91405, France ; , Cambridge CB3 0WA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. E.","family":"Moulton","sequence":"additional","affiliation":[{"name":"Mathematical Institute, University of Oxford , Oxford OX2 6GG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Waters","sequence":"additional","affiliation":[{"name":"Mathematical Institute, University of Oxford , Oxford OX2 6GG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"issue":"2\u20133","key":"2023020115153579400_bib1","first-page":"e86","article-title":"Kidney Stones: A Global Picture of Prevalence, Incidence, and Associated Risk Factors","volume":"12","year":"2010","journal-title":"Rev. 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