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Yet, the mutual interaction of cardiac patches with healthy tissue has not been completely understood. Here, we investigated the impact of acellular and cellular patches on a beating two-dimensional (2D) cardiac cell layer, and the effect of the beating of this layer on the cells encapsulated in the patch. We cultured human-induced pluripotent stem cell-derived cardiomyocytes (iCMs) on a coverslip and placed gelatin methacryloyl hydrogel alone or with encapsulated iCMs to create acellular and cellular patches, respectively. When the acellular patch was placed on the cardiac cell layer, the beating characteristics and Ca+2 handling properties reduced, whereas placing the cellular patch restored these characteristics. To better understand the effects of the cyclic contraction and relaxation induced by the beating cardiac cell layer on the patch placed on top of it, a simulation model was developed, and the calculated strain values were in agreement with the values measured experimentally. Moreover, this dynamic culture induced by the beating 2D iCM layer on the iCMs encapsulated in the cellular patch improved their beating velocity and frequency. Additionally, the encapsulated iCMs were observed to be coupled with the underlying beating 2D iCM layer. Overall, this study provides a detailed investigation on the mutual relationship of acellular\/cellular patches with the beating 2D iCM layer, understanding of which would be valuable for developing more advanced cardiac patches.<\/jats:p>","DOI":"10.1115\/1.4062736","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:15:15Z","timestamp":1687241715000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":3,"title":["An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation"],"prefix":"10.1115","volume":"145","author":[{"given":"Gozde","family":"Basara","sequence":"first","affiliation":[{"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame , 225 Multidisciplinary Research Building, Notre Dame, IN 46556"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Bahcecioglu","sequence":"additional","affiliation":[{"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame , 108B Multidisciplinary Research Building, Notre Dame, IN 46556"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame , Notre Dame, IN 46556"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Zorlutuna","sequence":"additional","affiliation":[{"name":"Department of Aerospace and Mechanical Engineering, University of Notre Dame , Notre Dame, IN 46556 ; , Notre Dame, IN 46556"},{"name":"Department of Chemical and Biomolecular Engineering, University of Notre Dame, 143 Multidisciplinary Research Building , Notre Dame, IN 46556 ; , Notre Dame, IN 46556"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"issue":"6","key":"2024062100015435800_bib1","first-page":"1","article-title":"Deaths: Leading Causes for 2017","volume":"68","year":"2019","journal-title":"Natl. 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