{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:20:57Z","timestamp":1785435657510,"version":"3.56.0"},"reference-count":39,"publisher":"ASME International","issue":"10","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FPU20\/07393"],"award-info":[{"award-number":["FPU20\/07393"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004233","name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","doi-asserted-by":"publisher","award":["PAID-06-23"],"award-info":[{"award-number":["PAID-06-23"]}],"id":[{"id":"10.13039\/501100004233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Computational fluid dynamics (CFD) simulations are widely used to develop and analyze blood-contacting medical devices such as left ventricular assist devices (LVADs). This work presents an analysis of the transient behavior of two centrifugal LVADs with different designs: HeartWare VAD and HeartMate3. A scale-resolving methodology is followed through Large Eddy Simulations, which allows for the visualization of turbulent structures. The three-dimensional (3D) LVAD models are coupled to a zero-dimensional (0D) 2-element Windkessel model, which accounts for the vascular resistance and compliance of the arterial system downstream of the device. Furthermore, both continuous- and pulsatile-flow operation modes are analyzed. For the pulsatile conditions, the artificial pulse of HeartMate3 is imposed, leading to a larger variation of performance variables in HeartWare VAD than in HeartMate3. Moreover, CFD results of pulsatile-flow simulations are compared to those obtained by accessing the quasi-steady maps of the pumps. The quasi-steady approach is a predictive tool used to provide a preliminary approximation of the pulsatile evolution of flow rate, pressure head, and power, by only imposing a speed pulse and vascular parameters. This preliminary quasi-steady solution can be useful for deciding the characteristics of the pulsatile speed law before running a transient CFD simulation, as the former entails a significant reduction in computational cost in comparison to the latter.<\/jats:p>","DOI":"10.1115\/1.4065418","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:37:05Z","timestamp":1714383425000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":2,"title":["Transient Performance Analysis of Centrifugal Left Ventricular Assist Devices Coupled With Windkessel Model: Large Eddy Simulations Study on Continuous and Pulsatile Flow Operation"],"prefix":"10.1115","volume":"146","author":[{"given":"Antonio","family":"Gil","sequence":"first","affiliation":[{"name":"Clean Mobility & Thermofluids, Universitat Polit\u00e8cnica de Val\u00e8ncia , Camino de Vera, s\/n , Val\u00e8ncia 46022, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Navarro","sequence":"additional","affiliation":[{"name":"Clean Mobility & Thermofluids, Universitat Polit\u00e8cnica de Val\u00e8ncia , Camino de Vera, s\/n , Val\u00e8ncia 46022, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Quintero","sequence":"additional","affiliation":[{"name":"Clean Mobility & Thermofluids, Universitat Polit\u00e8cnica de Val\u00e8ncia , Camino de Vera, s\/n , Val\u00e8ncia 46022, Spain"},{"id":[{"id":"https:\/\/ror.org\/01460j859","id-type":"ROR","asserted-by":"publisher"}],"name":"Universitat Polit\u00e8cnica de Val\u00e8ncia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-6710","authenticated-orcid":false,"given":"Andrea","family":"Mares","sequence":"additional","affiliation":[{"name":"Clean Mobility & Thermofluids, Universitat Polit\u00e8cnica de Val\u00e8ncia , Camino de Vera, s\/n , Val\u00e8ncia 46022, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024051315082587900_bib1","article-title":"Cardiovascular Diseases","author":"World Health Organization,","year":"2021"},{"issue":"1","key":"2024051315082587900_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ehf2.12005","article-title":"Heart Failure: Preventing Disease and Death Worldwide","volume":"1","year":"2014","journal-title":"ESC Hear. 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