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It employs a topology optimization method to drive the remodeling process and uses a pixel function to describe the structural topology and bone density distribution. Unlike traditional approaches based on strain energy density or compliance, this study adopts von Mises stress to guide the remodeling of LIF. A novel pixel interpolation scheme associated with stress criteria is applied to the physical properties of the bone, directly addressing the stress shielding effect caused by the implanted cage, which significantly influences the bone remodeling outcome in LIF. Additionally, a boundary inverse approach is utilized to reconstruct a simplified analysis model. To reduce computational cost while maintaining high structural resolution and accuracy, the scaled boundary finite element method (SBFEM) is introduced. The proposed numerical approach successfully generates results that closely resemble human lumbar interbody fusion.<\/jats:p>","DOI":"10.1115\/1.4066369","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T11:35:58Z","timestamp":1724844958000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":4,"title":["Topology Optimization Driven Bone-Remodeling Simulation for Lumbar Interbody Fusion"],"prefix":"10.1115","volume":"146","author":[{"given":"Zuowei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Neurospine Center, China International Neuroscience Institute , Beijing 100530, China"},{"id":[{"id":"https:\/\/ror.org\/013xs5b60","id-type":"ROR","asserted-by":"publisher"}],"name":"Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, International Research Center for Computational Mechanics, Dalian University of Technology, Dalian 116023, China ; , No. 26 Yucai Road, Jiangbei District, Ningbo 315016, China"},{"name":"Ningbo Institute of Dalian University of Technology Dalian 116023, China ; , No. 26 Yucai Road, Jiangbei District, Ningbo 315016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, International Research Center for Computational Mechanics, Dalian University of Technology , Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, International Research Center for Computational Mechanics, Dalian University of Technology , Dalian 116023, China"},{"id":[{"id":"https:\/\/ror.org\/023hj5876","id-type":"ROR","asserted-by":"publisher"}],"name":"Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Mei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, International Research Center for Computational Mechanics, Dalian University of Technology, Dalian 116023, China ; , No. 26 Yucai Road, Jiangbei District, Ningbo 315016, China"},{"name":"Ningbo Institute of Dalian University of Technology Dalian 116023, China ; , No. 26 Yucai Road, Jiangbei District, Ningbo 315016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"issue":"1","key":"2024092109484495500_bib1","first-page":"2","article-title":"Lumbar Interbody Fusion: Techniques, Indications and Comparison of Interbody Fusion Options Including PLIF, TLIF, MI-TLIF, OLIF\/ATP, LLIF and ALIF","volume":"3","year":"2015","journal-title":"J. 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