{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:00:08Z","timestamp":1768093208258,"version":"3.49.0"},"reference-count":38,"publisher":"ASME International","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR073231, AR069619"],"award-info":[{"award-number":["AR073231, AR069619"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Collagen XI is ubiquitous in tissues such as joint cartilage, cancellous bone, muscles, and tendons and is an important contributor during a crucial part in fibrillogenesis. The COL11A1 gene encodes one of three alpha chains of collagen XI. The present study elucidates the role of collagen XI in the establishment of mechanical properties of tendons and ligaments. We investigated the mechanical response of three tendons and one ligament tissues from wild type and a targeted mouse model null for collagen XI: Achilles tendon (ACH), the flexor digitorum longus tendon (FDL), the supraspinatus tendon (SST), and the anterior cruciate ligament (ACL). Area was substantially lower in Col11a1\u0394Ten\/\u0394Ten ACH, FDL, and SST. Maximum load and maximum stress were significantly lower in Col11a1\u0394Ten\/\u0394Ten ACH and FDL. Stiffness was lower in Col11a1\u0394Ten\/\u0394Ten ACH, FDL, and SST. Modulus was reduced in Col11a1\u0394Ten\/\u0394Ten FDL and SST (both insertion site and midsubstance). Collagen fiber distributions were more aligned under load in both wild type group and Col11a1\u0394Ten\/\u0394Ten groups. Results also revealed that the effect of collagen XI knockout on collagen fiber realignment is tendon-dependent and location-dependent (insertion versus midsubstance). In summary, this study clearly shows that the regulatory role of collagen XI on tendon and ligament is tissue specific and that joint hypermobility in type II Stickler's Syndrome may in part be due to suboptimal mechanical response of the soft tissues surrounding joints.<\/jats:p>","DOI":"10.1115\/1.4066570","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T13:34:17Z","timestamp":1726752857000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":4,"title":["Regulatory Role of Collagen XI in the Establishment of Mechanical Properties of Tendons and Ligaments in Mice Is Tissue Dependent"],"prefix":"10.1115","volume":"147","author":[{"given":"Yaping","family":"Ye","sequence":"first","affiliation":[{"name":"McKay Orthopaedic Research Laboratory, University of Pennsylvania , Philadelphia, PA 19104 ; , Wuhan, Hubei 430030, China"},{"name":"Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Philadelphia, PA 19104 ; , Wuhan, Hubei 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehal S.","family":"Shetye","sequence":"additional","affiliation":[{"name":"McKay Orthopaedic Research Laboratory, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Birk","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology & Physiology, University of South Florida , Tampa, FL 33647"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J.","family":"Soslowsky","sequence":"additional","affiliation":[{"name":"McKay Orthopaedic Research Laboratory, University of Pennsylvania , Philadelphia, PA 19104-6081"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"1","key":"2024101814541382500_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.103.1.231","article-title":"Extracellular Compartments in Tendon Morphogenesis: Collagen Fibril, Bundle, and Macroaggregate Formation","volume":"103","year":"1986","journal-title":"J. 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