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One application of this route is to modify the distribution of solutes in the CSF; however, few tools currently exist for this purpose. The present study describes the use of a subject-specific in vitro CSF phantom to perform a parametric evaluation of the Neurapheresis\u2122 CSF Management System (NP) for both CSF filtration and intrathecal drug circulation. An in vitro CSF phantom was constructed which included realistic anatomy for the complete subarachnoid space (SAS). This platform was configured to test multiple parametric modifications of a dual-lumen catheter and filtration system. Calibrated mapping of tracer distribution and area under the curve (AUC) measurements were used to compare filtration and intrathecal-circulation schemes using the NP device versus the clinical standards of care. The NP device showed potential advantages over lumbar drain (LD) for clearance of simulated subarachnoid hemorrhage (SAH), especially in the spinal canal. Use of the NP device in combination with simulated intracerebroventricular (ICV) drug infusion resulted in an increased extent and uniformity of tracer spread compared to ICV alone. NP improved clearance of simulated subarachnoid hemorrhage compared to LD and increased uniformity of tracer concentration via simulated ICV, providing support for NP use in these scenarios. The in vitro CSF phantom system presented here quantitatively described the effects of parametric boundary modification on solute distribution in the intrathecal space.<\/jats:p>","DOI":"10.1115\/1.4066862","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:15:41Z","timestamp":1728904541000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":1,"title":["An In Vitro Platform for Pharmacokinetic Quantification and Optimization of Cerebrospinal Fluid Filtration and Drug Circulation"],"prefix":"10.1115","volume":"19","author":[{"given":"Lucas R.","family":"Sass","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering, University of Idaho , 875 Perimeter Drive, Moscow, ID 83844"},{"id":[{"id":"https:\/\/ror.org\/03hbp5t65","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Khani","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, University of Idaho , 875 Perimeter Drive, Moscow, ID 83844"},{"id":[{"id":"https:\/\/ror.org\/03hbp5t65","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Minnetronix Medical , 1635 Energy Park Drive, St. Paul, MN 55108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Minnetronix Medical , 1635 Energy Park Drive, St. Paul, MN 55108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivanand P.","family":"Lad","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University , 200 Trent Drive, Durham, NC 27705"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, University of Idaho , 875 Perimeter Drive, Moscow, ID 83844 ; , Moscow, ID 83843"},{"name":"Flux Neuroscience, LLC , 875 Perimeter Drive, Moscow, ID 83844 ; , Moscow, ID 83843"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"1","key":"2024110816090601900_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The Blood-Brain Barrier: Bottleneck in Brain Drug Development","volume":"2","year":"2005","journal-title":"NeuroRx"},{"issue":"4","key":"2024110816090601900_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00281-009-0177-0","article-title":"The Blood-Brain and the Blood-Cerebrospinal Fluid Barriers: Function and Dysfunction","volume":"31","year":"2009","journal-title":"Semin. 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