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Circumferential and axial strips were collected from nine axial and two circumferential sites along each autopsied aorta, yielding 1188 samples (11 aortas\u2009\u00d7 18 sites\u2009\u00d7\u20092 directions\u2009\u00d7\u20093 layers per site). These samples underwent tear testing to assess tear strength and tear energy, constituting resistance to tear propagation. Adventitial tear parameters were significantly higher than those of the intima and media, with no significant differences between the latter two, supporting the observation that entry tears typically occur in the inner wall. Tear propagation angles were approximately 15 and 75\u2009deg for circumferential and axial medial strips, and 30 and 45\u2009deg for circumferential and axial strips of the intima and adventitia, with minimal variation along the aorta. These findings indicate that the media, and to a lesser extent the other layers, have higher resistance to axial tearing compared to circumferential tearing, aligning with the clinical observation of circumferentially directed tears. Intimal and adventitial tear parameters increased modestly along the aorta, while medial parameters varied less, explaining why entry tears rarely originate in the abdominal aorta. Tear parameters in inner and outer quadrants were similar at most axial locations, except for dissimilar tear propagation angles of the intima and adventitia in the proximal aorta (especially the arch), explaining why entry tears seldom involve the entire circumference.<\/jats:p>","DOI":"10.1115\/1.4067912","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:15:46Z","timestamp":1739531746000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":3,"title":["Variation in Layer-Specific Tear Properties of the Human Aorta Along Its Length and Circumference: Implications for Spatial Susceptibility to Dissection Initiation"],"prefix":"10.1115","volume":"147","author":[{"given":"Dimitrios P.","family":"Sokolis","sequence":"first","affiliation":[{"name":"Laboratory of Biomechanics, Center of Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens , 4 Soranou Ephesiou Street, Athens 115, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"2025030510393337800_bib1","first-page":"3","article-title":"Aortic Function","volume-title":"Functional Abnormalities of the Aorta","author":"Boudoulas","year":"1996"},{"key":"2025030510393337800_bib2","volume-title":"McDonald's Blood Flow in Arteries. 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