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To understand the range of susceptibilities to glaucoma, we aimed to identify key factors influencing LC oxygenation and examine if these factors vary with anatomical differences between eyes. We reconstructed three-dimensional, eye-specific LC vessel networks from histological sections of four healthy monkey eyes. For each network, we generated 125 models varying vessel radius, oxygen consumption rate, and arteriole perfusion pressure. Using hemodynamic and oxygen supply modeling, we predicted blood flow distribution and tissue oxygenation in the LC. ANOVA assessed the significance of each parameter. Our results showed that vessel radius had the greatest influence on LC oxygenation, followed by anatomical variations. Arteriole perfusion pressure and oxygen consumption rate were the third and fourth most influential factors, respectively. The LC regions are well perfused under baseline conditions. These findings highlight the importance of vessel radius and anatomical variation in LC oxygenation, providing insights into LC physiology and pathology. Pathologies affecting vessel radius may increase the risk of LC hypoxia, and anatomical variations could influence susceptibility. Conversely, increased oxygen consumption rates had minimal effects, suggesting that higher metabolic demands, such as those needed to maintain intracellular transport despite elevated intra-ocular pressure (IOP), have limited impact on LC oxygenation.<\/jats:p>","DOI":"10.1115\/1.4068577","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:57:58Z","timestamp":1746183478000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":1,"title":["Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors"],"prefix":"10.1115","volume":"147","author":[{"given":"Yuankai","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh , Pittsburgh, PA 15219"},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh , Pittsburgh, PA 15219; , Oxford, MS 38677; , Oxford, MS 38677"},{"name":"Department of Biomedical Engineering, University of Mississippi , Pittsburgh, PA 15219; , Oxford, MS 38677; , Oxford, MS 38677"},{"name":"Department of Mechanical Engineering, University of Mississippi , Pittsburgh, PA 15219; , Oxford, MS 38677; , Oxford, MS 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-5438","authenticated-orcid":false,"given":"Po-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh , Pittsburgh, PA 15219; , Pittsburgh, PA 38677"},{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15219; , Pittsburgh, PA 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Theophanous","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15261"},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaharoz","family":"Tahir","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15261"},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15261"},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Sigal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh , Pittsburgh, PA 15219 ; , Pittsburgh, PA 15261"},{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15219 ; , Pittsburgh, PA 15261"},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"issue":"8","key":"2025061111490922400_bib1","first-page":"606","article-title":"The Dynamics and Location of Axonal Transport Blockade by Acute Intraocular Pressure Elevation in Primate Optic Nerve","volume":"15","year":"1976","journal-title":"Invest. 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