{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:37:02Z","timestamp":1785418622036,"version":"3.56.0"},"reference-count":52,"publisher":"ASME International","issue":"9","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The present work characterized mechanical properties of human and porcine cornea along nasal\u2013temporal (NT) and superior\u2013inferior (SI) directions. Because of easy accessibility and comparable dimensions, porcine cornea has been widely used for investigating human corneal properties. Here, similarities and differences between human and porcine corneal biomechanics were characterized using a biaxial testing machine (ElectroForce Planar Biaxial TestBench, TA Instruments, New Castle, DE) and a uniaxial testing device (RSA-G2 Solids Analyzer, TA Instruments, New Castle, DE). Furthermore, transmission electron microscopy (TEM) was done to characterize the microstructure of samples. The biaxial and uniaxial experiments showed that neither human nor porcine cornea had anisotropic tensile properties along SI and NT directions. The tensile properties obtained from uniaxial tests were significantly lower than biaxial measurements (P\u2009&amp;lt;\u20090.05). Both testing methods gave significantly larger peak stress and tangent modulus for human cornea (p\u2009&amp;lt;\u20090.05). In comparison with those of porcine cornea, the human corneal collagen fibril diameter (FD), interfibrillar spacing (IFS), and lamellar projected thickness were significantly smaller (P\u2009&amp;lt;\u20090.05). The lamellar projected thickness of each species along SI and NT directions was significantly different (P\u2009&amp;lt;\u20090.05). The differences and similarities between mechanical response of porcine and human cornea were discussed in terms of microstructure of their extracellular matrices. It was concluded that improving awareness among researchers about mechanical differences between human and porcine cornea is essential.<\/jats:p>","DOI":"10.1115\/1.4068828","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:36:42Z","timestamp":1749116202000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":1,"title":["Microstructure and In-Plane Mechanical Property Comparison of Human and Porcine Cornea"],"prefix":"10.1115","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-2121","authenticated-orcid":false,"given":"Hamed","family":"Hatami-Marbini","sequence":"first","affiliation":[{"name":"Mechanical and Industrial Engineering Department, University of Illinois Chicago , 2033 Engineering Research Facility, 842 W. Taylor Street, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Esharuzzaman","family":"Emu","sequence":"additional","affiliation":[{"name":"Mechanical and Industrial Engineering Department, University of Illinois Chicago , Chicago, IL 60607"},{"id":[{"id":"https:\/\/ror.org\/02mpq6x41","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Illinois Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"2025070706394212200_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-0-387-73906-9","article-title":"The Cornea and Sclera","volume-title":"Collagen: Structure and Mechanics","author":"Fratzl","year":"2008"},{"issue":"3","key":"2025070706394212200_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10237-023-01801-7","article-title":"The Inclusion of the Epithelium in Numerical Models of the Human Cornea","volume":"23","year":"2024","journal-title":"Biomech. 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