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To explore the concept's feasibility, computational modeling of general diaphyseal and distal femur fractures treated with both rigid and compliant plates is conducted. In Part I of this study, a diaphyseal fracture finite element model for novel compliant plates is validated against experimental data with good agreement. In Part II, a parametric analysis is conducted using the validated model to characterize the performance of many compliant plate designs with varying geometry and materials. Under axial loading, all compliant plate configurations provided greater (1.03\u2009mm versus 0.22\u2009mm) and more symmetric (270\u2013390%) axial interfragmentary motion than rigid plates. Steel compliant plates with thicker flexures (0.3\u20130.6\u2009mm) may provide the best performance given their enhanced motion and comparable bending\/torsional rigidity. In Part III, compliant plates are adapted for use in treating distal femur fractures. Results demonstrate that compared to a rigid plate, a compliant distal femur plate with increased thickness can effectively modulate interfragmentary motion\u2014that is, increase the insufficient near cortex motion under low loads (from 0.14\u2009mm to 0.23\u2009mm) and reduce the excessive far cortex motion under large loads (from 7.96\u2009mm to 2.54\u2009mm). Flexure-based locking plates represent a promising new approach to treating diaphyseal and\/or distal femur fractures. Additional research is needed to investigate in vivo performance.<\/jats:p>","DOI":"10.1115\/1.4070406","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T11:17:31Z","timestamp":1763205451000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":2,"title":["Flexure-Based Locking Plates Can Modulate Interfragmentary Motion in Distal Femur and Diaphyseal Fractures: A Parametric Finite Element Analysis"],"prefix":"10.1115","volume":"148","author":[{"given":"Connor","family":"Huxman","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Penn State University , University Park, PA 16802"},{"id":[{"id":"https:\/\/ror.org\/04p491231","id-type":"ROR","asserted-by":"publisher"}],"name":"Pennsylvania State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Updegrove","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Penn State College of Medicine , Hershey, PA 17033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Penn State College of Medicine , Hershey, PA 17033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwabok","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Penn State College of Medicine , Hershey, PA 17033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary I.","family":"Frecker","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Penn State University , University Park, PA 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Butler","sequence":"additional","affiliation":[{"name":"School of Engineering Design and Innovation, Penn State University , University Park, PA 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Penn State College of Medicine , Hershey, PA 17033"},{"id":[{"id":"https:\/\/ror.org\/04p491231","id-type":"ROR","asserted-by":"publisher"}],"name":"Pennsylvania State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"issue":"4","key":"2025121709044070100_bib1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1302\/0301-620X.67B4.4030869","article-title":"The Influence of Induced Micromovement Upon the Healing of Experimental Tibial Fractures","volume":"67-B","year":"1985","journal-title":"J. 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