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This phenomenon is known as cellular mechanical memory that occurs in three phases: memory acquisition, storage, and recall. The literature supports a model in which mechanical experiences become encoded through interconnected cytoskeletal, nuclear, metabolic, and epigenetic mechanisms. Mechanical memory is increasingly recognized as a central regulator of cell fate and tissue remodeling, as well as a fundamental principle in development, aging, fibrosis, cancer, and regenerative medicine. We here give a concise overview of the historical origins and defining features of mechanical memory, discuss the emergence of mechanical memory in aqueous humor outflow dysfunction in glaucoma, summarize key unanswered questions, and close with a discussion of the clinical relevance of targeting mechanical memory for therapeutic purposes.<\/jats:p>","DOI":"10.1115\/1.4072760","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:47:45Z","timestamp":1791820065000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":0,"title":["The Emerging Role of Cellular Mechanical Memory in Aqueous Humor Outflow Dysfunction in Glaucoma"],"prefix":"10.1115","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-2010","authenticated-orcid":false,"given":"Samuel","family":"Herberg","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University , 505 Irving Avenue, Neuroscience Research Building Room 4609 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13244 ;\u2009 , Syracuse, NY 13244"},{"name":"Department of Cell and Developmental Biology, SUNY Upstate Medical University , 505 Irving Avenue, Neuroscience Research Building Room 4609 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13244 ;\u2009 , Syracuse, NY 13244"},{"name":"Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University , 505 Irving Avenue, Neuroscience Research Building Room 4609 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13244 ;\u2009 , Syracuse, NY 13244"},{"name":"BioInspired Institute, Syracuse University , 505 Irving Avenue, Neuroscience Research Building Room 4609 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13244 ;\u2009 , Syracuse, NY 13244"},{"name":"Department of Biomedical and Chemical Engineering, Syracuse University , 505 Irving Avenue, Neuroscience Research Building Room 4609 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13210 ;\u2009 , Syracuse, NY 13244 ;\u2009 , Syracuse, NY 13244"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"5751","key":"2026102111344997100_bib1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue Cells Feel and Respond to the Stiffness of Their Substrate","volume":"310","year":"2005","journal-title":"Science"},{"issue":"1","key":"2026102111344997100_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-bioeng-071811-150021","article-title":"Biophysical Cues and Cell Behavior: The Big Impact of Little Things","volume":"15","year":"2013","journal-title":"Annu. 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