{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:42:03Z","timestamp":1792402923777,"version":"4.4.0"},"reference-count":0,"publisher":"ASME International","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biomechanical factors play a crucial role in glaucoma development, the world-leading cause of irreversible blindness. Although age is known to affect the tissues? biomechanical properties, early-onset menopause has recently been associated with the risk of developing glaucoma, and the effects of aging relative to early-onset menopause on eye?s biomechanical factors remain underexplored. This work?s goals were to study the effects of aging and early-onset menopause on intraocular pressure (IOP), aqueous humor outflow facility, and ocular compliance.<\/jats:p>\n                  <jats:p>Female Brown Norway rats underwent Sham or surgical menopause (ovariectomy; OVX) at 3-4 months of age and were split into young (5-6 months) or middle-aged groups (9-10 months). We monitored IOP until the established aging time points and performed ex vivo biomechanical measurements via the iPerfusion system.<\/jats:p>\n                  <jats:p>IOP was higher for the middle-aged Sham and OVX animals by 25% and 35%, respectively (p&amp;lt;0.001), when compared to their respective initial IOPs. Furthermore, middle-aged OVX animals had a 11% higher IOP compared to Sham animals (p=0.005), and a 20% lower outflow facility (p=0.031). Ocular compliance decreased with age in the Sham (24.9%, p=0.011) and OVX (24.5%, p=0.005) cohorts and by 24.1% independent of cohort (p=0.0001).<\/jats:p>\n                  <jats:p>Elucidating the effects of age and early-onset menopause on biomechanical factors that contribute to glaucoma pathology is necessary to help move the field forward and preserve the eyesight of millions of patients.<\/jats:p>","DOI":"10.1115\/1.4072763","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:09:07Z","timestamp":1792400947000},"page":"1-33","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Aging and Early-Onset Menopause on Intraocular Pressure (IOP) and Aqueous Humor Conventional Outflow Facility"],"prefix":"10.1115","author":[{"given":"Nina Sara","family":"Fraticelli-Guzm\u00e1n","sequence":"first","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States ;\u2009 ;"},{"name":"Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, United States ;\u2009 ;"},{"name":"Bioengineering Interdisciplinary Program, Georgia Institute of Technology, Atlanta, GA, United States ;\u2009 ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beam","family":"Yongphiphatwong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"van Batenburg-Sherwood","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Feola","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, United States ;\u2009 ;\u2009 ;"},{"name":"Bioengineering Interdisciplinary Program, Georgia Institute of Technology, Atlanta, GA, United States ;\u2009 ;\u2009 ;"},{"name":"Center for Visual and Neurocognitive Rehabilitation, Joseph M. Cleland Atlanta VA Medical Center, Decatur, GA, United States ;\u2009 ;\u2009 ;"},{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United State ;\u2009 ;\u2009 ;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2026,10,19]]},"container-title":["Journal of Biomechanical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/doi\/10.1115\/1.4072763\/7647951\/bio-26-1116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article-pdf\/doi\/10.1115\/1.4072763\/7647951\/bio-26-1116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:09:08Z","timestamp":1792400948000},"score":1,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/biomechanical\/article\/doi\/10.1115\/1.4072763\/1236706\/Effects-of-Aging-and-Early-Onset-Menopause-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1115\/1.4072763","relation":{},"ISSN":["0148-0731","1528-8951"],"issn-type":[{"value":"0148-0731","type":"print"},{"value":"1528-8951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]}}}