{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T20:35:28Z","timestamp":1725654928042},"reference-count":4,"publisher":"ASMEDC","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:p>This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems and evaluation of their mechanical properties. We have proposed drug delivery systems (DDS) using shock waves in order to apply micro\/nano technology in the fields of biomedical engineering. In this system, a microcapsule including a gas bubble is flown in the blood vessel, and finally broken by shock induced microjet, then drug is reached to the affected part in the body as same as traditional DDS. In this paper, the mechanism for deformation and disintegration of capsules in our previous works is reviewed, and the trials of making special microcapsules are discussed. To determine Young\u2019s modulus of capsule membrane mentioned above, the membrane is deformed by the aspiration device and the deformation is compared with computational result by FEM.<\/jats:p>","DOI":"10.1115\/imece2005-80697","type":"proceedings-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T17:13:18Z","timestamp":1207242798000},"page":"15-18","update-policy":"http:\/\/dx.doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":0,"title":["Prototype of Microcapsule Including a Gas Bubble for Developing Shock Wave Drug Delivery Systems"],"prefix":"10.1115","author":[{"given":"Masaaki","family":"Tamagawa","sequence":"first","affiliation":[{"name":"Kyushu Institute of Technology"}]},{"given":"Ichiro","family":"Yamanoi","sequence":"additional","affiliation":[{"name":"Kyushu Institute of Technology"}]}],"member":"33","published-online":{"date-parts":[[2008,2,5]]},"reference":[{"key":"2020010910032364000_r1","unstructured":"Genenger B. 1997, \u201cVerfahren zum Aufschluss von Gasfoemige Stoffwechse-produkte erzeugenden mikroorganismen,\u201d PATENT Nr-DE-197 15 819"},{"key":"2020010910032364000_r2","doi-asserted-by":"crossref","unstructured":"Tamagawa M. , AkamatsuT. 2001, JSME Intl J. C44\u20134, 1031\u20131040","DOI":"10.1299\/jsmec.44.1031"},{"key":"2020010910032364000_r3","doi-asserted-by":"crossref","unstructured":"Tamagawa M. et al. J. Acoust. Am., 2000, 108\u20135, 25472547","DOI":"10.1121\/1.429504"},{"key":"2020010910032364000_r4","unstructured":"Tamagawa, M. et. al, IMECE 2004-59675, Anaheim"}],"event":{"name":"ASME 2005 International Mechanical Engineering Congress and Exposition","start":{"date-parts":[[2005,11,5]]},"sponsor":["Bioengineering Division"],"location":"Orlando, Florida, USA","end":{"date-parts":[[2005,11,11]]},"acronym":"IMECE2005"},"container-title":["Advances in Bioengineering"],"original-title":[],"link":[{"URL":"http:\/\/asmedigitalcollection.asme.org\/IMECE\/proceedings-pdf\/doi\/10.1115\/IMECE2005-80697\/4558038\/15_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/asmedigitalcollection.asme.org\/IMECE\/proceedings-pdf\/doi\/10.1115\/IMECE2005-80697\/4558038\/15_1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T12:36:52Z","timestamp":1684327012000},"score":1,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/IMECE\/proceedings\/IMECE2005\/42134\/15\/308730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":4,"URL":"https:\/\/doi.org\/10.1115\/imece2005-80697","relation":{},"subject":[],"published":{"date-parts":[[2005,1,1]]}}}