{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:32:19Z","timestamp":1777894339144,"version":"3.51.4"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aim: Orofacial clefts comprise cleft lip (CL) or cleft lip-palate (CLP) and are the most frequently encountered malformation\u00a0of the facial region, accounting for approximately 1-2.2\/1,000 live births. The aim of this study was to reveal the particularities\u00a0regarding the prenatal diagnosis of orofacial clefts in a series of 11 cases diagnosed in a tertiary center.Material and\u00a0methods: The study was performed in a tertiary diagnostic center for a period of 8 years (January 2010 \u2013 December 2017), on8125 patients that were assessed for screening or suspicion of malformations.Results: During the assessed period a number of\u00a011 fetuses (0.13%) were diagnosed by 2D and 3D ultrasound with CL (4 cases) or CLP (7 cases). The smallest gestational age at diagnosis was of 14 weeks, whereas the highest was 35 weeks. Of the 7 cases diagnosed with CLP, 4 presented also other\u00a0associated anomalies that involved the central nervous system, the kidney, the skeleton and the stomach. All 4 cases of CL had\u00a0identifiable associated anomalies. Termination of pregnancy was encountered in 3 cases with CLP.Conclusions: CLP can be\u00a0diagnosed even at the end of the 1st trimester of pregnancy. CL is usually diagnosed during the 2nd trimester ultrasound exam\u00a0and is commonly an isolated anomaly.<\/jats:p>","DOI":"10.11152\/mu-1582","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T12:29:46Z","timestamp":1529929786000},"page":"531","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal diagnosis of cleft lip and cleft lip palate \u2013 a case series"],"prefix":"10.11152","volume":"20","author":[{"given":"Claudiu","family":"Marginean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladut","family":"Sasarean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Oana","family":"Marginean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Elena","family":"Melit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Oana","family":"Marginean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4840","published-online":{"date-parts":[[2018,12,8]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/1582\/1255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/1582\/1255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T02:54:58Z","timestamp":1544237698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/1582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,8]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12,8]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-1582","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,8]]}}}