{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:41:16Z","timestamp":1792586476543,"version":"4.5.0"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aim: Holoprosencephaly (HPE) is the most common brain malformation. A wide spectrum of anatomical variants are\u00a0characterized by a lack of midline separation of the cerebral hemispheres. The aim of this study was to assess the ultrasound\u00a0diagnostic criteria for HPE.Material and method: A database of 175 fetuses with central nervous system anomalies identified\u00a0by ultrasound was collected retrospectively from 2006 to 2016 in this multicenter, retrospective, observational study. Among\u00a0them 18 cases (10.2%) with HPE were identified.Results: The prevalence of HPE was 2.5:10.000 with the sex distributionmale:female of 1:1.6. Six cases were alobar subtype, 3 were semilobar, 7 were lobar and 2 were middle interhemispheric variant.\u00a0In the second trimester, we consider that the abnormal fusion of the lateral ventricles and the absence of the cavum septum\u00a0pellucidum are the most important landmarks for HPE. Facial abnormalities varied considerably.Conclusion: This study illustrates\u00a0the heterogeneity of HPE with different cerebral and facial appearances.<\/jats:p>","DOI":"10.11152\/mu-1614","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T02:08:12Z","timestamp":1549937292000},"page":"163","source":"Crossref","is-referenced-by-count":5,"title":["The wide spectrum of ultrasound diagnosis of holoprosencephaly"],"prefix":"10.11152","volume":"21","author":[{"given":"Cringu Antoniu","family":"Ionescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Vladareanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Tudorache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Ples","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin","family":"Herghelegiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Neacsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Navolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Dragan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Nuti","family":"Oprescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4840","published-online":{"date-parts":[[2019,5,2]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/1614\/1330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/1614\/1330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T10:47:05Z","timestamp":1557139625000},"score":1,"resource":{"primary":{"URL":"https:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/1614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,2]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,2]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-1614","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,2]]}}}