{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:01:20Z","timestamp":1783177280228,"version":"3.54.6"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aims: To estimate the prevalence of autosomal dominant polycystic kidney disease (ADPKD) and provide the evaluation\u00a0of new ultrasonographic criteria and clinical indicators to help its early detection.Materials and methods: A total of 30750\u00a0individuals for health check-up with abdominal ultrasonography (US) were included, in which 231 suspects of ADPKD based\u00a0on the number of renal cysts were extracted. They were divided into 4 groups by the grade of suspicion (definitive, a strong\u00a0suspect, a fair suspect and a weak suspect). Longitudinal data of US and renal function tests were compared between the\u00a0groups.The estimated prevalence rate was 0.068% from the study subjects. The level of eGFR did not differ between the definitive\u00a0and suspects, while the annual estimated glomerular filtration ratio (eGFR) decline was significantly larger in the former\u00a0(p&lt;0.001). The subjects with growing renal cysts showed a larger annual eGFR decline than those without growth (p=0.0324).\u00a0The proposed cut-off set at the first quartile of the annualized eGFR change efficiently divided the subjects according to the\u00a0presence of cyst growth (p= 0.027) and the grade of suspicion of ADPKD (p=0.028).Conclusion: The prevalence rate of\u00a0ADPKD was higher than the corresponding rate previously reported in Japan (0.025%), suggesting that health check-ups may\u00a0be an efficient opportunity to pick up undiagnosed ADPKD. The large annual eGFR decline and the presence of growing cysts\u00a0may be feasible indicators to isolate ADPKD and should be introduced into US based screening to facilitate early detectionof ADPKD.<\/jats:p>","DOI":"10.11152\/mu-3330","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T16:47:09Z","timestamp":1636562829000},"page":"140","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological estimates and early detection of polycystic kidney disease by ultrasonographic assessment in Japan"],"prefix":"10.11152","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6859-7064","authenticated-orcid":false,"given":"Minoru","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Kamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4840","published-online":{"date-parts":[[2022,5,25]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/3330\/1967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/3330\/1967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T18:44:58Z","timestamp":1654281898000},"score":1,"resource":{"primary":{"URL":"https:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/3330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,5,25]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-3330","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,25]]}}}