{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:45:08Z","timestamp":1776091508565,"version":"3.50.1"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aims: To investigate the correlation between time-intensity curve (TIC) parameters obtained from transrectal contrast-enhanced\u00a0ultrasound (TR-CEUS) and important pathological prognostic factors in rectal adenocarcinoma.Material and methods:\u00a0We retrospectively included 477 patients with pathologically confirmed rectal adenocarcinoma. TIC parameters were\u00a0derived from preoperative dynamic TR-CEUS images. These parameters included peak intensity (PI), time to peak (TTP),mean transit time (MTT), slope (S), and area under the curve (AREA). Pathological prognostic factors included TN stage,\u00a0tumor diameter, lymphovascular invasion (LVI), perineural invasion, and tumor differentiation. Spearman\u2019s correlation analysis\u00a0and binary logistic regression were used to analyze the association between TIC parameters and pathological prognostic\u00a0factors.Results: pT1-2 stages rectal carcinomas exhibited higher PI-max, PI-min, S-max, S-min, AREA-max, and AREA-min\u00a0than pT3-4 stages (all p&lt;0.05). pN0 stage rectal adenocarcinomas displayed higher PI-max, S-max, AREA-max, PI-ratio, Sratio,\u00a0and AREA-ratio than pN1-2 stage (all p&lt;0.05). PI-ratio and S-ratio were higher in the LVI-negative and tumor diameter\u00a0\u22654cm group compared to the LVI-positive and tumor diameter &lt;4cm group, respectively (p&lt;0.05). Well-differentiated rectal\u00a0adenocarcinomas displayed higher PI-max, AREA-max, PI-ratio, S-ratio, and AREA-ratio than the moderate-poor differentiated\u00a0group (all p&lt;0.05). PI-max, S-max, AREA-max, PI-ratio, S-ratio, and AREA-ratio were negatively correlated with pN\u00a0stage (all p&lt;0.05). PI-ratio and S-ratio were independent predictive factors for the pN stage (OR=0.774, OR=1.048). S-ratio\u00a0and AREA-ratio were independent predictive factors for tumor differentiation (OR=1.071, OR=0.911).Conclusions: TIC parameters\u00a0derived from TR-CEUS exhibit correlations with specific pathological prognostic factors in rectal adenocarcinomas.\u00a0This non-invasive method may hold promise for preoperatively assessing the prognosis of rectal adenocarcinoma patients.<\/jats:p>","DOI":"10.11152\/mu-4375","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T09:09:40Z","timestamp":1715764180000},"page":"233","source":"Crossref","is-referenced-by-count":3,"title":["The correlation between time-intensity curve parameters of transrectal contrast-enhanced ultrasound and pathological prognostic factors in rectal adenocarcinoma"],"prefix":"10.11152","volume":"26","author":[{"given":"Shitao","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanzhang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xigui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangyong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4840","published-online":{"date-parts":[[2024,9,16]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/4375\/2373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/4375\/2373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T08:06:36Z","timestamp":1726473996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/4375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9,16]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-4375","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,16]]}}}