{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:12:02Z","timestamp":1773879122960,"version":"3.50.1"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aims: This study aimed to evaluate the diagnostic performance of shear wave elastography (SWE) in differentiating non-melanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), from benign skin\u00a0lesions. A secondary objective was to assess the accuracy of high-resolution ultrasonography (HRUS) for preoperative tumormeasurement.Material and methods: A prospective study was conducted on 106 patients with clinically suspected NMSC\u00a0or benign lesions (nevi). Each lesion was evaluated with SWE and HRUS using an 18 MHz probe, followed by surgical excision and histopathological confirmation. Among the confirmed malignancies, 46 were BCC and 15 SCC. The control group\u00a0included 35 nevi diagnosed clinically and dermatoscopically. SWE stiffness values were compared across lesion types. Tumor\u00a0length and depth measured by HRUS were validated against pathology using The Student\u2019s t-test or Mann\u2013Whitney U test,\u00a0Bland\u2013Altman analysis and the Intraclass Correlation Coefficient (ICC).Results: SWE showed significantly higher stiffness\u00a0in malignant versus benign lesions, with optimal thresholds of &gt;13 kPa for BCC and &gt;15 kPa for SCC. The area under the\u00a0receiver operating characteristic curve (AUROC), was 0.95 for BCC and 0.99 for SCC. Differentiation between SCC and\u00a0BCC was moderate (AUROC=0.70). HRUS accurately estimated tumor length (bias=1.31 mm, p&gt;0.05; ICC=0.90), while\u00a0depth was slightly overestimated (bias=0.87 mm, p&lt;0.05; ICC=0.83).Conclusion: SWE and HRUS offer complementary,\u00a0non-invasive tools for the diagnosis and preoperative assessment of BCC and SCC. SWE demonstrated high diagnostic accuracy for distinguishing NMSC from benign lesions, particularly nevi, by applying stiffness thresholds between 13\u201315 kPa.\u00a0HRUS proved effective in estimating tumor length with good agreement to histopathology, though it showed a tendency to\u00a0overestimate tumor depth.<\/jats:p>","DOI":"10.11152\/mu-4540","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:56:30Z","timestamp":1756302990000},"page":"51","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of Shear Wave Elastography and high-resolution ultrasound in non-melanoma skin cancer: a study of basal and squamous cell carcinomas"],"prefix":"10.11152","volume":"28","author":[{"given":"Amalia","family":"Moisoiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Maria","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor","family":"Moisoiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Bocsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Filip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Baican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Ungureanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorina","family":"D\u0103nescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"\u0218enil\u0103","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Baican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Fodor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4840","published-online":{"date-parts":[[2026,3,18]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/4540\/2671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/4540\/2671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:39:34Z","timestamp":1773855574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/4540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,18]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-4540","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,18]]}}}