{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:25:29Z","timestamp":1784366729950,"version":"3.55.0"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aims: Our aim was to evaluate the elasticity features of the optic nerve using strain (SE) and shear wave elastography\u00a0(SWE) in multiple sclerosis (MS) patients in comparison with healthy subjects. Material and methods: One hundred and\u00a0seven optic nerves from 54 MS patients and 118 optic nerves from 59 healthy subjects were examined prospectively by SE\u00a0and SWE. Optic nerves were divided into three types in accordance to the elasticity designs, as follows: type 1 predominantly\u00a0blue (hardest tissue); type 2 predominantly blue\/green (hard tissue); and type 3 predominantly green (intermediate tissue).\u00a0Quantitative measurements of optic nerve hardness with SWE were analyzed in kilopascals. Results: Elastographic images\u00a0from healthy volunteers showed mostly type 3 optic nerves (61.9%); type 2 was also found (38.1%), but type 1 was not observed.\u00a0Elastographic examination of MS patients showed mostly type 2 optic nerves (88%), while some type 1 (4.6%) and\u00a0type 3 optic nerves (6.5%) were rarely observed. There was a statistically significant difference in terms of elasticity patterns\u00a0between patients and healthy volunteers (p&lt;0.001). Statistically significant differences were observed between patients and\u00a0healthy volunteers in the analysis of SWE values (10.381\u00b13.48 kPa and 33.87\u00b111.64 p&lt;0.001). The receiver operating characteristic\u00a0curve analysis was perfect (0.993; 95% confidence interval [CI]=0.971\u20130.999), and a cut-off value of 18.3 kPa shear\u00a0had very high sensitivity and specificity for the patient group. No significant differences were observed between patients with\u00a0and without previous optic neuritis. Conclusion: SE and SWE examination findings concerning the optic nerve in MS patients\u00a0demonstrated remarkable differences according to the healthy group.<\/jats:p>","DOI":"10.11152\/mu-939","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T07:35:13Z","timestamp":1485934513000},"page":"39","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects"],"prefix":"10.11152","volume":"19","author":[{"given":"Mikail","family":"\u0130nal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan M.","family":"Yumusak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Hamdi","family":"\u015eahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Alpua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"\u00d6rnek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4840","published-online":{"date-parts":[[2017,1,31]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"http:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/939\/902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/939\/902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T07:35:18Z","timestamp":1485934518000},"score":1,"resource":{"primary":{"URL":"http:\/\/medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,31]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-939","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}