{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:07:26Z","timestamp":1777446446480,"version":"3.51.4"},"reference-count":0,"publisher":"SRUMB - Romanian Society for Ultrasonography in Medicine and Biology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Ultrason"],"abstract":"<jats:p>Aim: Accurate diagnosis and early treatment in rheumatoid arthritis (RA) can lead to a good outcome and a correct management\u00a0of the disease. We aimed toinvestigate the prognostic value of anti-RA33 antibodies, by evaluating the relationship\u00a0with ultrasonographic (US) findings in patients with early RA.Material and methods: We performed a prospective study\u00a0which included 29 patients, diagnosed with early RA according to the ACR\/EULAR 2010 criteria and 21 sex and age-matched\u00a0control subjects. All patients underwent clinical and biological assessment, followed by US examination in grayscale (GS) and\u00a0power Doppler (PD) at baseline and after 12 months [from the second to the fifth metacarpophalangeal (MCP) and proximal\u00a0interphalangeal (PIP) joints and wrists (RCC), in dorsal aspect]. The second and fifth MCP joints were scanned also in lateral\u00a0aspects.Results: The initial GS evaluation revealed the presence of synovitis in all 29 patients; PD found at least one joint\u00a0with a PD grade higher than 1 in 23 patients, higher than 2 in 20 patients, and grade 3 in 6 patients; at 12 months, we revealed\u00a0the presence of GSUS synovitis in 25 patients and PDUS examination found active synovitis in 12 subjects. In those patients,\u00a0the anti-RA33 titre was significantly lower compared to those without PDUS active synovitis (p=0.031), with a moderately\u00a0negative correlation (r=-0.519, p=0.0039).Conclusions: The current study shows that anti-RA33 antibodies might constitute\u00a0an additional tool for diagnosing early RA patients and can help identify patients with mild disease and a low level of activesynovitis.<\/jats:p>","DOI":"10.11152\/mu-995","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T09:29:32Z","timestamp":1488533372000},"page":"166","source":"Crossref","is-referenced-by-count":8,"title":["High frequency ultrasonography of the hand versus anti-RA33 evaluation in early rheumatoid arthritis - a pilot study"],"prefix":"10.11152","volume":"19","author":[{"given":"Andreea Lili","family":"Barbulescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina Lucia","family":"Ciurea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mitran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice Andreea","family":"Chisalau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Dorina","family":"Parvanescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sineta Cristina","family":"Firulescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Balasoiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihail Virgil","family":"Boldeanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horatiu","family":"Popoviciu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentin Ananu","family":"Vreju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4840","published-online":{"date-parts":[[2017,4,22]]},"container-title":["Medical Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/995\/949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/viewFile\/995\/949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T16:33:40Z","timestamp":1492878820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medultrason.ro\/medultrason\/index.php\/medultrason\/article\/view\/995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,22]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,4,22]]}},"URL":"https:\/\/doi.org\/10.11152\/mu-995","relation":{},"ISSN":["2066-8643","1844-4172"],"issn-type":[{"value":"2066-8643","type":"electronic"},{"value":"1844-4172","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4,22]]}}}