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Here, the authors focused on the alignment on an array of grooves of nanometer depth using two cell types: healthy osteoprogenitor primary cells (HOP) and a cancerous osteosarcoma (SaOs-2) cell line. Another concern was how this alignment affects the cell's interior, namely, the nucleus. Based on the results, it is proposed that these two cell types respond to different size regimes: SaOs-2 cells are more sensitive to shallow grooves while HOP cells are strongly aligned with deep grooves. As a measure of the impact of cell alignment on the nucleus the orientation and elongation of the nucleus were determined. Compared to HOP cells, the cell nucleus of SaOs-2 cells is more aligned and elongated in response to grooves, suggesting a softer nucleus and\/or increased force transmission. These results support the hypothesis that cancer cells have reduced nucleus rigidity compared to healthy ones and further indicate differences in sensing, which may be important during metastasis.<\/jats:p>","DOI":"10.1116\/1.4927556","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T13:00:28Z","timestamp":1438347628000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Different surface sensing of the cell body and nucleus in healthy primary cells and in a cancerous cell line on nanogrooves"],"prefix":"10.1116","volume":"10","author":[{"given":"Patricia M.","family":"Davidson","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Haute-Alsace Institut de Science des Mat\u00e9riaux de Mulhouse, CNRS UMR7361, , Mulhouse 68057, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxence","family":"Bigerelle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Valenciennes et du Hainaut Cambr\u00e9sis LAMIH, Mechanical Department, CNRS UMR 8201, , Valenciennes 59313, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Reiter","sequence":"additional","affiliation":[{"name":"Albert-Ludwigs-University of Freiburg Institute of Physics, Faculty of Mathematics and Physics, , Freiburg 79104, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Anselme","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Haute-Alsace Institut de Science des Mat\u00e9riaux de Mulhouse, CNRS UMR7361, , Mulhouse 68057, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"2023062417281594700_c1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev-bioeng-071811-150021","volume":"15","year":"2013","journal-title":"Annu. 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