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Nine potential catalysts were investigated for the reaction between PEG and divinyl sulfone, among which 4-dimethylaminopyridine (DMAP) prevailed for its high catalytic activity. DMAP produced PEG-VS with a conversion of more than 90% in 2\u2009h under a solvent-free condition at room temperature, which significantly simplifies the synthesis of PEG-VS. The preparation of PEG hydrogels was realized by adding glycerol as a crosslinker, and the physical and the mechanical properties were easily controlled by changing the crosslinker concentration as well as the PEG chain length. This strategy can also be applied to other polyhydroxy compounds as crosslinkers, and thus, a library of hydrogels with designed structures and desired properties could be prepared. The PEG hydrogels showed good antifouling properties, low cytotoxicity, and ability to release drugs at a tunable rate, indicating versatile potential bioapplications.<\/jats:p>","DOI":"10.1116\/1.4984305","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T12:44:37Z","timestamp":1496321077000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Poly(ethylene) glycol hydrogel based on oxa-Michael reaction: Precursor synthesis and hydrogel formation"],"prefix":"10.1116","volume":"12","author":[{"given":"Hanqi","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"},{"name":"School of Pharmaceutical Science and Technology, Dalian University of Technology , Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"},{"name":"School of Pharmaceutical Science and Technology, Dalian University of Technology , Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"},{"name":"Department of Polymer Science and Engineering, School of Chemical Engineering, Dalian University of Technology , Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaohui","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology, Dalian University of Technology State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China and , Dalian, Liaoning 116023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Illinois at Chicago , Chicago, Illinois 60607"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, Liaoning 116023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"2023062715271254600_c1","doi-asserted-by":"publisher","first-page":"4639","DOI":"10.1016\/j.biomaterials.2010.02.044","volume":"31","year":"2010","journal-title":"Biomaterials"},{"key":"2023062715271254600_c2","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1039\/C3PY00869J","volume":"5","year":"2014","journal-title":"Polym. 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