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The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface. Distinct mass spectral signals were detected from different regions of the tissue (epidermis, dermis, hair follicles, sebaceous glands, scar tissue, and cancerous tissue) allowing mass spectral pathology to be performed. The cancerous regions of the tissue showed a particular increase in sphingomyelin signals that were detected in both positive and negative ion mode along with increased specific phosphatidylserine and phosphatidylinositol signals observed in negative ion mode. Samples containing mixed more and less aggressive tumor regions showed increased phosphatidylcholine lipid content in the less aggressive areas similar to a punch biopsy sample of a nonaggressive nodular lesion.<\/jats:p>","DOI":"10.1116\/1.5016254","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T09:31:59Z","timestamp":1515749519000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry"],"prefix":"10.1116","volume":"13","author":[{"given":"Marwa","family":"Munem","sequence":"first","affiliation":[{"name":"Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg 412 96,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Zaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg 413 45,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Dimovska Nilsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg 412 96,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noora","family":"Neittaanm\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg , 413 45,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Paoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg 413 45,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, University of Gothenburg , Gothenburg 412 96,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"key":"2025100218015394200_c1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1684\/ejd.2014.2271","volume":"24","year":"2014","journal-title":"Eur. 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