{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:23:50Z","timestamp":1762867430516,"version":"3.41.2"},"reference-count":29,"publisher":"American Vacuum Society","issue":"4","funder":[{"name":"High Technology Research and Development Program of China","award":["2015AA034702"],"award-info":[{"award-number":["2015AA034702"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51772209"],"award-info":[{"award-number":["51772209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>One of the key challenges in engineering tissues for cell-based therapies is developing biocompatible scaffold materials to direct cell behavior. In this paper, the cytocompatibilities of a flexible three-dimensional graphene scaffold (3D-G) and the same scaffold implanted with nitrogen ions (N+\/3D-G) are compared using an in vitro assay based on 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The N+\/3D-G samples were prepared from low-temperature hydrothermally synthesized flexible 3D-G by ion implantation and were found to display improved adhesion and proliferation of rat osteoblast and mouse fibroblast cells. In particular, the N+\/3D-G sample with a nitrogen content of \u223c10% showed the highest levels of cell viability and proliferation. The flexible N+\/3D-G has potential applications as a biocompatible scaffold material that provides improved surface area and hydrophilic groups for cell growth and proliferation.<\/jats:p>","DOI":"10.1116\/1.5025534","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T19:33:03Z","timestamp":1526499183000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced cell growth on 3D graphene scaffolds implanted with nitrogen ions"],"prefix":"10.1116","volume":"13","author":[{"given":"Mengli","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Physics and Materials Science, Tianjin Normal University 1 , Tianjin 300387, China"},{"name":"Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University 2 , Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Physics and Materials Science, Tianjin Normal University 1 , Tianjin 300387, China"},{"name":"Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University 2 , Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Physics and Materials Science, Tianjin Normal University 1 , Tianjin 300387, China"},{"name":"Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University 2 , Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiu","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Physics and Materials Science, Tianjin Normal University 1 , Tianjin 300387, China"},{"name":"Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University 2 , Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Physics and Materials Science, Tianjin Normal University 1 , Tianjin 300387, China"},{"name":"Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University 2 , Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Physics and Materials Science, Tianjin Normal University 1 , Tianjin 300387, China"},{"name":"Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University 2 , Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongxin","family":"Wan","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Urological Surgery, Tianjin Medical University 3 , Tianjin 300070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanqing","family":"Gu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Urological Surgery, Tianjin Medical University 3 , Tianjin 300070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"2023062317414873300_c1","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s11434-014-0158-0","volume":"59","year":"2014","journal-title":"Chin. 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