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Protein fibrils have also attracted interest as building blocks for new materials. It has long been recognized that surfaces can affect the fibrillation process. Recent work on the model fibril forming protein human islet amyloid polypeptide (hIAPP) has shown that while the protein concentration is highest at hydrophobic surfaces, the rate of fibril formation is lower than on other surfaces. To understand this, replica exchange molecular dynamics simulations were used to investigate the conformations that hIAPP adopts on surfaces of different hydrophobicities. The hydrophobic surface stabilizes \u03b1-helical structures which are significantly different to those found on the hydrophilic surface and in bulk solution. There is also a greatly reduced conformational ensemble on the hydrophobic surface due to long-lived contacts between hydrophobic residues on the protein and the surface. This new microscopic information will help us determine the mechanism of the enhancement of fibril formation on surfaces and provides new insight into the effect of nanointerfaces and protein conformation.<\/jats:p>","DOI":"10.1116\/6.0000417","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T07:20:38Z","timestamp":1599204038000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Effect of surface chemistry on islet amyloid polypeptide conformation"],"prefix":"10.1116","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-2295","authenticated-orcid":false,"given":"David L.","family":"Cheung","sequence":"first","affiliation":[{"name":"School of Chemistry, National University of Ireland Galway , Galway H91 TK33,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"2025100315220987600_c1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","year":"2006","journal-title":"Annu. 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