{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:03:33Z","timestamp":1782950613425,"version":"3.54.5"},"reference-count":56,"publisher":"American Vacuum Society","issue":"2","content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>Hepatocellular carcinoma (HCC) has become an important public health problem, and there are still challenges to overcome in clinical treatment. The nanodrug delivery system (NDDS) has developed tremendously in recent years, and many researchers have explored NDDS for the treatment of HCC. Engineered cell membrane-coated nanoparticles (ECNPs) have emerged, combining the unique functions of cell membranes with the engineering versatility of synthetic nanoparticles (NPs) to effectively deliver therapeutic drugs. It is designed to have the capabilities: specific active targeting, immune evasion, prolonging the circulation blood time, controlled drug release delivery, and reducing drugs systematic toxicity. Thus, ECNPs are a promising bionic tool in the treatment of HCC and have operability to achieve combination and integrated therapy. This review focuses on the mechanism and strategy of ECNPs for the treatment of HCC and summarizes its research progress in the treatment of HCC in recent years.<\/jats:p>","DOI":"10.1116\/6.0003204","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T12:37:00Z","timestamp":1712925420000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Engineered cell membrane-coated nanoparticles based cancer therapy: A robust weapon against the lethal and challenging hepatocellular carcinoma"],"prefix":"10.1116","volume":"19","author":[{"given":"Jiachen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital, The Second Military Medical University 1 , Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Caolu Community Health Service Center 2 , Shanghai 201209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital, The Second Military Medical University 1 , Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"2024041212365649000_c1","author":"Today C"},{"key":"2024041212365649000_c2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1159\/000530495","volume":"12","year":"2023","journal-title":"Liver Cancer"},{"key":"2024041212365649000_c3","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","volume":"380","year":"2019","journal-title":"New Eng. J. Med."},{"key":"2024041212365649000_c4","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.1021\/acsbiomaterials.7b00514","volume":"4","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2024041212365649000_c5","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1039\/C9TB02871D","volume":"8","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"2024041212365649000_c6","doi-asserted-by":"publisher","first-page":"10980","DOI":"10.1073\/pnas.1106634108","volume":"108","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024041212365649000_c7","doi-asserted-by":"publisher","first-page":"13481","DOI":"10.1073\/pnas.1412420111","volume":"111","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024041212365649000_c8","doi-asserted-by":"publisher","first-page":"11374","DOI":"10.1039\/c3nr01541f","volume":"5","year":"2013","journal-title":"Nanoscale"},{"key":"2024041212365649000_c9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/pharmaceutics12010021","volume":"12","year":"2020","journal-title":"Pharmaceutics"},{"key":"2024041212365649000_c10","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3892\/mco.2014.356","volume":"2","year":"2014","journal-title":"Mol. Clin. Oncol."},{"key":"2024041212365649000_c11","doi-asserted-by":"publisher","first-page":"7340","DOI":"10.1002\/adma.201601498","volume":"28","year":"2016","journal-title":"Adv. Mater."},{"key":"2024041212365649000_c12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.2174\/1389200219666180925094515","volume":"20","year":"2019","journal-title":"Curr. Drug Metab."},{"key":"2024041212365649000_c13","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1189\/jlb.0606394","volume":"80","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2024041212365649000_c14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.devcel.2010.06.013","volume":"19","year":"2010","journal-title":"Dev. Cell"},{"key":"2024041212365649000_c15","doi-asserted-by":"publisher","first-page":"5120","DOI":"10.1038\/s41467-020-18794-x","volume":"11","year":"2020","journal-title":"Nat. Commun."},{"key":"2024041212365649000_c16","doi-asserted-by":"publisher","first-page":"eaax7964","DOI":"10.1126\/sciadv.aax7964","volume":"5","year":"2019","journal-title":"Sci. Adv."},{"key":"2024041212365649000_c17","doi-asserted-by":"publisher","first-page":"107624","DOI":"10.1016\/j.intimp.2021.107624","volume":"99","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"2024041212365649000_c18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12951-019-0494-y","volume":"17","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"2024041212365649000_c19","doi-asserted-by":"publisher","first-page":"7194","DOI":"10.1039\/C9RA09233A","volume":"10","year":"2020","journal-title":"RSC Adv."},{"key":"2024041212365649000_c20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrc3004","volume":"11","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"2024041212365649000_c21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1177\/0885328218772721","volume":"33","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"2024041212365649000_c22","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1039\/D0TB00735H","volume":"8","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"2024041212365649000_c23","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.drudis.2018.02.001","volume":"23","year":"2018","journal-title":"Drug Discov. Today"},{"key":"2024041212365649000_c24","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.3390\/cancers11121836","volume":"11","year":"2019","journal-title":"Cancers"},{"key":"2024041212365649000_c25","doi-asserted-by":"publisher","first-page":"5828","DOI":"10.7150\/thno.34837","volume":"9","year":"2019","journal-title":"Theranostics"},{"key":"2024041212365649000_c26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ijbiomac.2022.12.235","volume":"228","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"2024041212365649000_c27","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1039\/C8BM00343B","volume":"6","year":"2018","journal-title":"Biomater. Sci."},{"key":"2024041212365649000_c28","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1002\/jbm.a.37387","volume":"110","year":"2022","journal-title":"J. Biomed. Mater. Res. A"},{"key":"2024041212365649000_c29","doi-asserted-by":"publisher","first-page":"40288","DOI":"10.1039\/C8RA07574C","volume":"8","year":"2018","journal-title":"RSC Adv."},{"key":"2024041212365649000_c30","doi-asserted-by":"publisher","first-page":"7006","DOI":"10.1021\/acsnano.7b02533","volume":"11","year":"2017","journal-title":"ACS Nano"},{"key":"2024041212365649000_c31","doi-asserted-by":"publisher","first-page":"12096","DOI":"10.1021\/acsnano.8b05292","volume":"12","year":"2018","journal-title":"ACS Nano"},{"key":"2024041212365649000_c32","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.2147\/IJN.S115727","volume":"11","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"2024041212365649000_c33","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/10717544.2021.2015481","volume":"29","year":"2022","journal-title":"Drug Deliv."},{"key":"2024041212365649000_c34","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1021\/acs.molpharmaceut.8b00881","volume":"15","year":"2018","journal-title":"Mol. Pharm."},{"key":"2024041212365649000_c35","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.jconrel.2022.03.060","volume":"345","year":"2022","journal-title":"J. Control Release"},{"key":"2024041212365649000_c36","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1056\/NEJMoa1215134","volume":"368","year":"2013","journal-title":"New Eng. J. Med."},{"key":"2024041212365649000_c37","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1182\/blood-2011-04-348540","volume":"118","year":"2011","journal-title":"Blood"},{"key":"2024041212365649000_c38","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1182\/blood-2011-10-384388","volume":"119","year":"2012","journal-title":"Blood"},{"key":"2024041212365649000_c39","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.7150\/thno.40291","volume":"10","year":"2020","journal-title":"Theranostics"},{"key":"2024041212365649000_c40","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12951-021-01095-w","volume":"19","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"2024041212365649000_c41","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.actbio.2020.04.046","volume":"111","year":"2020","journal-title":"Acta Biomater."},{"key":"2024041212365649000_c42","doi-asserted-by":"publisher","first-page":"e2200477","DOI":"10.1002\/advs.202200477","volume":"9","year":"2022","journal-title":"Adv. Sci."},{"key":"2024041212365649000_c43","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12951-020-00617-2","volume":"18","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"2024041212365649000_c44","doi-asserted-by":"publisher","first-page":"6260","DOI":"10.1021\/acsami.2c14962","volume":"15","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2024041212365649000_c45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.biomaterials.2018.09.021","volume":"185","year":"2018","journal-title":"Biomaterials"},{"key":"2024041212365649000_c46","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nbt.1549","volume":"27","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"2024041212365649000_c47","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1039\/C6NR09862B","volume":"9","year":"2017","journal-title":"Nanoscale"},{"key":"2024041212365649000_c48","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13046-014-0057-x","volume":"33","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2024041212365649000_c49","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"2024041212365649000_c50","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00262-014-1633-9","volume":"64","year":"2015","journal-title":"Cancer Immunol. Immunother."},{"key":"2024041212365649000_c51","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.actbio.2014.11.041","volume":"14","year":"2015","journal-title":"Acta Biomater."},{"key":"2024041212365649000_c52","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1053\/j.gastro.2021.06.008","volume":"161","year":"2021","journal-title":"Gastroenterology"},{"key":"2024041212365649000_c53","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1126\/science.342.6165.1432","volume":"342","year":"2013","journal-title":"Science"},{"key":"2024041212365649000_c54","doi-asserted-by":"publisher","first-page":"201","DOI":"10.12336\/biomatertransl.2022.03.004","volume":"3","year":"2022","journal-title":"Biomater. Transl."},{"key":"2024041212365649000_c55","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/apha.12352","volume":"213","year":"2015","journal-title":"Acta Physiol."},{"key":"2024041212365649000_c56","doi-asserted-by":"publisher","first-page":"e10559","DOI":"10.1002\/btm2.10559","volume":"8","year":"2023","journal-title":"Bioeng. Transl. Med."}],"container-title":["Biointerphases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/avs\/bip\/article-pdf\/doi\/10.1116\/6.0003204\/19880421\/020801_1_6.0003204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/avs\/bip\/article-pdf\/doi\/10.1116\/6.0003204\/19880421\/020801_1_6.0003204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T12:37:11Z","timestamp":1712925431000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/bip\/article\/19\/2\/020801\/3282695\/Engineered-cell-membrane-coated-nanoparticles"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1116\/6.0003204","relation":{},"ISSN":["1934-8630","1559-4106"],"issn-type":[{"value":"1934-8630","type":"print"},{"value":"1559-4106","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3,1]]},"article-number":"020801"}}