{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:38:35Z","timestamp":1777048715198,"version":"3.51.4"},"reference-count":51,"publisher":"American Vacuum Society","issue":"2","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A6A1A10073079"],"award-info":[{"award-number":["NRF-2019R1A6A1A10073079"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016R1D1A1B02007197"],"award-info":[{"award-number":["NRF-2016R1D1A1B02007197"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2025-RISE-10-005"],"award-info":[{"award-number":["2025-RISE-10-005"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pubs.aip.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>Biliary stents are medical devices inserted into the bile duct to treat biliary strictures. However, inserted stents can become occluded within a few months after placement. In this study, the inner surface of a polyethylene (PE) tube was plasma-treated with helium (He), nitrogen (N2), oxygen (O2), and their gas mixtures to improve resistance to stent occlusion. Surface characteristics were analyzed by water contact angle (WCA) and x-ray photoelectron spectroscopy (XPS) measurements. In the WCA results, bare PE without plasma treatment was the most hydrophobic at 100.7\u00b0, whereas PE(He) plasma-treated with He gas became the most hydrophilic at 26.1\u00b0. XPS deconvolution analysis revealed that the PE(He) and PE(He\/N2) contained a considerable proportion of O 1s present as amide (\u2013CONH\u2013) groups exceeding 40%, whereas the other samples had proportions below 7%. The resistance to stent occlusion was verified through microbial and cancer cell adhesion assays. In the microbial adhesion assay, Escherichia coli (E. coli) was used, and PE(He) showed a statistically significant reduction in E. coli growth compared to bare PE. Inhibition of cancer cell adhesion was the most pronounced in PE(He) and PE(He\/N2), with reductions in fluorescence intensities of 75.5% and 81.5%, respectively. Overall, both surface hydrophilization and amidation were found to be effective in inhibiting the adhesion of organic contaminants. It was proposed that plasma surface treatment has the potential to improve resistance to biliary stent occlusion.<\/jats:p>","DOI":"10.1116\/6.0005132","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:49:43Z","timestamp":1777045783000},"update-policy":"https:\/\/doi.org\/10.1063\/aip-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Improving resistance to biliary stent occlusion by surface hydrophilization and amidation through plasma treatment to the inner surface of polyethylene tubes"],"prefix":"10.1116","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2671-6002","authenticated-orcid":false,"given":"Chanyong","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Physics, Sungkyunkwan University 1 , 31 Science Building 1, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-2814","authenticated-orcid":false,"given":"Sang-Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Animal and Food Sciences and Marketing, Konkuk University 2 , 120, Neungdong-ro, Gwangjin-gu, Seoul 05029,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-8893","authenticated-orcid":false,"given":"Heonyong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Institute of Nanosensor and Biotechnology, Dankook University 3 , 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-7099","authenticated-orcid":false,"given":"Youngsik","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Institute of Nanosensor and Biotechnology, Dankook University 3 , 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8015-3514","authenticated-orcid":false,"given":"Myounghyeon","family":"Kyoung","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Dankook University 4 , 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-2377","authenticated-orcid":false,"given":"Sujeong","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Institute of Nanosensor and Biotechnology, Dankook University 3 , 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-4126","authenticated-orcid":false,"given":"Hong Ja","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dankook University Hospital 5 , 201, Manghyang-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5784-5684","authenticated-orcid":false,"given":"Yun Je","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dankook University Hospital 5 , 201, Manghyang-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0072-7387","authenticated-orcid":false,"given":"Yong Ki","family":"Cho","sequence":"additional","affiliation":[{"name":"Customized Manufacturing R&D Department, Korea Institute of Industrial Technology 6 , 113-58, Seohaean-ro, Siheung-si, Gyeonggi-do 15014,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-627X","authenticated-orcid":false,"given":"Sunyoung","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Sangji University 7 , 83, Sangjidae-gil, Wonju-si, Gangwon state 26339,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9135-6878","authenticated-orcid":false,"given":"Hyewon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physics, Sungkyunkwan University 8 , 31 Science Building 1, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-5790","authenticated-orcid":false,"given":"Namwuk","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Physics, Sungkyunkwan University 8 , 31 Science Building 1, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7288-8497","authenticated-orcid":false,"given":"Donggeun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Physics, Sungkyunkwan University 8 , 31 Science Building 1, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"2026042411493621000_c1","volume-title":"Physiology, Digestion","year":"2024"},{"key":"2026042411493621000_c2","volume-title":"Physiology, Bile Secretion","year":"2024"},{"key":"2026042411493621000_c3","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.4240\/wjgs.v15.i7.1262","volume":"15","year":"2023","journal-title":"World J. Gastrointest. Surg."},{"key":"2026042411493621000_c4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/gastro\/gou072","volume":"3","year":"2015","journal-title":"Gastroenterol. Rep."},{"key":"2026042411493621000_c5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.15279\/kpba.2018.23.3.101","volume":"23","year":"2018","journal-title":"Korean J. Pancreas Biliary Tract"},{"key":"2026042411493621000_c6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.5946\/ce.2021.048","volume":"54","year":"2021","journal-title":"Clin. Endosc."},{"key":"2026042411493621000_c7","first-page":"1","volume":"39","year":"2009","journal-title":"Korean J. Gastrointest. Endosc."},{"key":"2026042411493621000_c8","first-page":"116","volume":"16","year":"2012","journal-title":"Biomater. Res."},{"key":"2026042411493621000_c9","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1007\/s10620-013-2607-z","volume":"58","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"2026042411493621000_c10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5946\/ce.2016.024","volume":"49","year":"2016","journal-title":"Clin. Endosc."},{"key":"2026042411493621000_c11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4253\/wjge.v4.i5.157","volume":"4","year":"2012","journal-title":"World J. Gastrointest. Endosc."},{"key":"2026042411493621000_c12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5946\/ce.2012.45.1.78","volume":"45","year":"2012","journal-title":"Clin. Endosc."},{"key":"2026042411493621000_c13","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1111\/jgh.15824","volume":"37","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2026042411493621000_c14","first-page":"1050","volume":"5","year":"2014","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"2026042411493621000_c15","doi-asserted-by":"publisher","first-page":"E1090","DOI":"10.1055\/s-0042-115173","volume":"4","year":"2016","journal-title":"Endosc. Int. Open"},{"key":"2026042411493621000_c16","doi-asserted-by":"publisher","first-page":"9833","DOI":"10.1021\/acs.iecr.4c01054","volume":"63","year":"2024","journal-title":"Ind. Eng. Chem. Res."},{"key":"2026042411493621000_c17","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1002\/sia.2611","volume":"40","year":"2008","journal-title":"Surf. Interface Anal."},{"key":"2026042411493621000_c18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/sia.5663","volume":"47","year":"2015","journal-title":"Surf. Interface Anal."},{"key":"2026042411493621000_c19","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1080\/01694243.2015.1006906","volume":"29","year":"2015","journal-title":"J. Adhes. Sci. Technol."},{"key":"2026042411493621000_c20","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/sia.7125","volume":"54","year":"2022","journal-title":"Surf. Interface Anal."},{"key":"2026042411493621000_c21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.carbon.2022.12.062","volume":"204","year":"2023","journal-title":"Carbon"},{"key":"2026042411493621000_c22","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1088\/0022-3727\/37\/6\/015","volume":"37","year":"2004","journal-title":"J. Phys. D:Appl. Phys."},{"key":"2026042411493621000_c23","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s11595-020-2312-7","volume":"35","year":"2020","journal-title":"J. Wuhan Univ. Technol.-Mater. Sci. Ed."},{"key":"2026042411493621000_c24","doi-asserted-by":"publisher","first-page":"484","DOI":"10.14133\/j.cnki.1008-9357.20211104001","volume":"35","year":"2022","journal-title":"J. Funct. Polym."},{"key":"2026042411493621000_c25","doi-asserted-by":"publisher","first-page":"e85569","DOI":"10.1371\/journal.pone.0085569","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"2026042411493621000_c26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s10856-018-6134-5","volume":"29","year":"2018","journal-title":"J. Mater. Sci.:Mater. Med."},{"key":"2026042411493621000_c27","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1038\/srep01765","volume":"3","year":"2013","journal-title":"Sci. Rep."},{"key":"2026042411493621000_c28","doi-asserted-by":"publisher","first-page":"038102","DOI":"10.1088\/1674-1056\/24\/3\/038102","volume":"24","year":"2015","journal-title":"Chin. Phys. B"},{"key":"2026042411493621000_c29","doi-asserted-by":"publisher","first-page":"7744","DOI":"10.3390\/app12157744","volume":"12","year":"2022","journal-title":"Appl. Sci."},{"key":"2026042411493621000_c30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1006\/jcis.2001.8172","volume":"248","year":"2002","journal-title":"J. Colloid Interface Sci."},{"key":"2026042411493621000_c31","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1002\/app.12925","volume":"90","year":"2003","journal-title":"J. Appl. Polym. Sci."},{"key":"2026042411493621000_c32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.memsci.2007.12.038","volume":"311","year":"2008","journal-title":"J. Membr. Sci."},{"key":"2026042411493621000_c33","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/BF02087551","volume":"39","year":"1994","journal-title":"Dig. Dis. Sci."},{"key":"2026042411493621000_c34","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/S0016-5107(93)70220-5","volume":"39","year":"1993","journal-title":"Gastrointest. Endosc."},{"key":"2026042411493621000_c35","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.tibtech.2013.01.017","volume":"31","year":"2013","journal-title":"Trends Biotechnol."},{"key":"2026042411493621000_c36","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jmst.2021.05.028","volume":"99","year":"2022","journal-title":"J. Mater. Sci. Technol."},{"key":"2026042411493621000_c37","doi-asserted-by":"publisher","first-page":"055005","DOI":"10.1088\/0963-0252\/20\/5\/055005","volume":"20","year":"2011","journal-title":"Plasma Sources Sci. Technol."},{"key":"2026042411493621000_c38","doi-asserted-by":"publisher","first-page":"9466","DOI":"10.1021\/la300822j","volume":"28","year":"2012","journal-title":"Langmuir"},{"key":"2026042411493621000_c39","doi-asserted-by":"publisher","first-page":"04F406","DOI":"10.1116\/1.5023693","volume":"36","year":"2018","journal-title":"J. Vac. Sci. Technol. A"},{"key":"2026042411493621000_c40","doi-asserted-by":"publisher","first-page":"185201","DOI":"10.1088\/1361-6463\/ab6d97","volume":"53","year":"2020","journal-title":"J. Phys. D:Appl. Phys."},{"key":"2026042411493621000_c41","volume-title":"Plasma Surface Modification and Plasma Polymerization","year":"1996"},{"key":"2026042411493621000_c42","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1163\/156856193X00600","volume":"7","year":"1993","journal-title":"J. Adhes. Sci. Technol."},{"key":"2026042411493621000_c43","doi-asserted-by":"publisher","first-page":"2300208","DOI":"10.1002\/ppap.202300208","volume":"21","year":"2024","journal-title":"Plasma Process. Polym."},{"key":"2026042411493621000_c44","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1163\/156856102760067217","volume":"16","year":"2002","journal-title":"J. Adhes. Sci. Technol."},{"key":"2026042411493621000_c45","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1163\/15685610252771185","volume":"16","year":"2002","journal-title":"J. Adhes. Sci. Technol."},{"key":"2026042411493621000_c46","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3390\/coatings9020145","volume":"9","year":"2019","journal-title":"Coatings"},{"key":"2026042411493621000_c47","doi-asserted-by":"publisher","first-page":"224007","DOI":"10.1088\/0022-3727\/47\/22\/224007","volume":"47","year":"2014","journal-title":"J. Phys. D:Appl. Phys."},{"key":"2026042411493621000_c48","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1002\/ppap.201500025","volume":"12","year":"2015","journal-title":"Plasma Process. Polym."},{"key":"2026042411493621000_c49","doi-asserted-by":"publisher","first-page":"015006","DOI":"10.1088\/1758-5082\/5\/1\/015006","volume":"5","year":"2013","journal-title":"Biofabrication"},{"key":"2026042411493621000_c50","doi-asserted-by":"publisher","first-page":"150058","DOI":"10.1016\/j.apsusc.2021.150058","volume":"561","year":"2021","journal-title":"Appl. Surf. Sci."},{"key":"2026042411493621000_c51","doi-asserted-by":"publisher","first-page":"100497","DOI":"10.1016\/j.apsadv.2023.100497","volume":"18","year":"2023","journal-title":"Appl. Surf. Sci. Adv."}],"container-title":["Biointerphases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.aip.org\/avs\/bip\/article-pdf\/doi\/10.1116\/6.0005132\/20984552\/021001_1_6.0005132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.aip.org\/avs\/bip\/article-pdf\/doi\/10.1116\/6.0005132\/20984552\/021001_1_6.0005132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:49:47Z","timestamp":1777045787000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.aip.org\/bip\/article\/21\/2\/021001\/3387903\/Improving-resistance-to-biliary-stent-occlusion-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1116\/6.0005132","relation":{},"ISSN":["1934-8630","1559-4106"],"issn-type":[{"value":"1934-8630","type":"print"},{"value":"1559-4106","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3,1]]},"article-number":"021001"}}