{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:23:20Z","timestamp":1791296600359,"version":"4.1.0"},"reference-count":33,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:p>The high fatality rate associated with the late detection of skin cancer makes early detection crucial in preventing death. The current method for determining if a skin lesion is suspect to cancer is initially based on the patient\u2019s and physician\u2019s subjective observation of the skin lesion. Physicians use a set of parameters called the ABCD (asymmetry, border, color, diameter) rule to help facilitate diagnosis of potential cancerous lesions. Lesions that are suspicious then require a biopsy, which is a painful, invasive, and a time-consuming procedure. In an attempt to reduce the aforementioned undesirable elements currently associated with skin cancer diagnosis, a novel optical polarization-imaging system is described that has the potential to noninvasively detect cancerous lesions. The described system generates the full 16-element Mueller matrix in less than 70 s. The operation of the system was tested in transmission, specular reflection, and diffuse reflectance modes, using known samples, such as a horizontal linear polarizer, a mirror, and a diffuser plate. In addition, it was also used to image a benign lesion on a human subject. The results of the known samples are in good agreement with their theoretical values with an average accuracy of 97.96% and a standard deviation of 0.0084, using 16 polarization images. The system accuracy was further increased to 99.44% with a standard deviation of 0.005, when 36 images were used to generate the Mueller matrix.<\/jats:p>","DOI":"10.1117\/1.1486248","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T15:29:17Z","timestamp":1033486157000},"page":"341-349","source":"Crossref","is-referenced-by-count":133,"title":["Development and calibration of an automated Mueller matrix polarization imaging system"],"prefix":"10.1117","volume":"7","author":[{"given":"Justin S.","family":"Baba","sequence":"first","affiliation":[{"name":"Texas A&M Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Rae","family":"Chung","sequence":"additional","affiliation":[{"name":"Texas A&M Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee H.","family":"DeLaughter","sequence":"additional","affiliation":[{"name":"Texas A&M Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent D.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Texas A&M Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-9625","authenticated-orcid":false,"given":"Gerard L.","family":"Cote","sequence":"additional","affiliation":[{"name":"Texas A&M Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"10.1117\/1.1486248_r1","unstructured":"What You Need to Know About Skin Cancer\n                      , NIH-National Cancer Institute, NIH Publication No. 95-1564 (1995)."},{"key":"10.1117\/1.1486248_r2","unstructured":"Cancer: Rates and Risks\n                      , NIH-National Cancer Institute, NIH Publication No. 96-691 (1996)."},{"key":"10.1117\/1.1486248_r3","unstructured":"The Melanoma Letter\n                      , The Skin Cancer Foundation, New York (2001)."},{"key":"10.1117\/1.1486248_r4","unstructured":"J. McMurry,\n                      Organic Chemistry\n                      , 3rd ed., Brooks\/Cole, Pacific Grove, CA (1992)."},{"key":"10.1117\/1.1486248_r5","unstructured":"B. E. R. Newlands,\n                      Sugar\n                      , Spon & Chamberlain, New York (1909)."},{"key":"10.1117\/1.1486248_r6","unstructured":"C. A. Browne and F. W. Zerban,\n                      Physical and Chemical Methods of Sugar Analysis\n                      , 3rd ed., Wiley, New York (1941)."},{"key":"10.1117\/1.1486248_r7","unstructured":"G. L. Spencer,\n                      A Handbook for Cane-Sugar Manufacturers\n                      , 6th ed., Wiley, New York (1917)."},{"key":"10.1117\/1.1486248_r8","unstructured":"M. A. Fox and J. K. Whitesell,\n                      Organic Chemistry\n                      , 2nd ed., Jones and Barlett, Sudbury, MA (1997)."},{"key":"10.1117\/1.1486248_r9","unstructured":"D. S. Eisenbergh and D. M. 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Einterz Randall,\n                      Polarized Light in Optics and Spectroscopy\n                      , p. 77, Academic, San Diego, CA (1990).","DOI":"10.1016\/B978-0-08-057104-1.50011-9"},{"key":"10.1117\/1.1486248_r28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1364\/OL.24.000537","volume":"24","author":"Yao","year":"1999","journal-title":"Opt. Lett.","ISSN":"https:\/\/id.crossref.org\/issn\/0146-9592","issn-type":"print"},{"key":"10.1117\/1.1486248_r29","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1119\/1.14202","volume":"53","author":"Bickel","year":"1985","journal-title":"Am. J. Phys.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9505","issn-type":"print"},{"key":"10.1117\/1.1486248_r30","unstructured":"B. D. Cameron,\n                      The Application of Polarized Light to Biomedical Diagnostics and Monitoring\n                      , PhD dissertation, Texas A&M University, College Station, TX (2000)."},{"key":"10.1117\/1.1486248_r31","unstructured":"H. C. Van de Hulst,\n                      Light Scattering by Small Particles\n                      , Dover, New York (1981)."},{"key":"10.1117\/1.1486248_r32","unstructured":"C. F. Bohren and D. R. Huffman,\n                      Absorption and Scattering of Light by Small Particles\n                      , Wiley, New York (1983)."},{"key":"10.1117\/1.1486248_r33","unstructured":"J. W. Nilsson and S. A. 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