{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:04:02Z","timestamp":1790816642556,"version":"4.1.0"},"reference-count":42,"publisher":"SPIE-Intl Soc Optical Eng","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:p>The ability of ultra-high-resolution optical coherence tomography (UHR OCT) to discriminate between healthy and pathological human brain tissue is examined by imaging ex vivo tissue morphology of various brain biopsies. Micrometer-scale OCT resolution (0.9\u00d72 \u00b5m, axial\u00d7lateral) is achieved in biological tissue by interfacing a state-of-the-art Ti:Al2O3 laser (c=800 nm, =260 nm, and Pout=120 mW exfiber) to a free-space OCT system utilizing dynamic focusing. UHR OCT images are acquired from both healthy brain tissue and various types of brain tumors including fibrous, athypical, and transitional meningioma and ganglioglioma. A comparison of the tomograms with standard hematoxylin and eosin (H&amp;E) stained histological sections of the imaged biopsies demonstrates the ability of UHR OCT to visualize and identify morphological features such as microcalcifications (&gt;20 \u00b5m), enlarged nuclei of tumor cells (~8 to 15 \u00b5m), small cysts, and blood vessels, which are characteristic of neuropathologies and normally absent in healthy brain tissue.<\/jats:p>","DOI":"10.1117\/1.1851513","type":"journal-article","created":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T18:00:59Z","timestamp":1113933659000},"page":"1-7","source":"Crossref","is-referenced-by-count":76,"title":["Imaging ex vivo healthy and pathological human brain tissue with ultra-high-resolution optical coherence tomography"],"prefix":"10.1117","volume":"10","author":[{"given":"Kostadinka K.","family":"Bizheva","sequence":"first","affiliation":[{"name":"Univ. of Waterloo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Unterhuber","sequence":"additional","affiliation":[{"name":"Medical Univ. 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